Drug nanoparticles by antisolvent precipitation mixing energy versus surfactant stabilization

Drug nanoparticles by antisolvent precipitation : mixing energy versus surfactant stabilization

Organic itraconazole (ITZ) solutions were mixed with aqueous solutions to precipitate sub-300 nm particles over a wide range of energy dissipation rates, even for drug loadings as high as 86% (ITZ weight/total weight). The small particle sizes were produced with the stabilizer poloxamer 407, which l...

Ausführliche Beschreibung

Bibliographische Detailangaben
Veröffentlicht in:Langmuir : the ACS journal of surfaces and colloids. - 1992. - 22(2006), 21 vom: 10. Okt., Seite 8951-9
1. Verfasser: Matteucci, Michal E (VerfasserIn)
Weitere Verfasser: Hotze, Margaret A, Johnston, Keith P, Williams, Robert O 3rd
Format: Aufsatz
Sprache:English
Veröffentlicht: 2006
Zugriff auf das übergeordnete Werk:Langmuir : the ACS journal of surfaces and colloids
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Solvents Surface-Active Agents Itraconazole 304NUG5GF4