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231223s2006 xx ||||| 00| ||eng c |
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|a pubmed24n0553.xml
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|a (DE-627)NLM16573003X
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|a (NLM)17014104
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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|a Selvam, Parthiban
|e verfasserin
|4 aut
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|a Surfactant design for the 1,1,1,2-tetrafluoroethane-water interface
|b ab initio calculations and in situ high-pressure tensiometry
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|c 2006
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|a Text
|b txt
|2 rdacontent
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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|a Band
|b nc
|2 rdacarrier
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|a Date Completed 06.09.2007
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|a Date Revised 20.11.2014
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|a published: Print
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|a Citation Status MEDLINE
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|a In situ high-pressure tensiometry and ab initio calculations were used to rationally design surfactants for the 1,1,1,2-tetrafluoroethane-water (HFA134a|W) interface. Nonbonded pair interaction (binding) energies (E(b)) of the complexes between HFA134a and candidate surfactant tails were used to quantify the HFA-philicity of selected moieties. The interaction between HFA134a and an ether-based tail was shown to be predominantly electrostatic in nature and much more favorable than that between HFA134a and a methyl-based fragment. The interfacial activity of (i) amphiphiles typically found in FDA-approved pressurized metered-dose inhaler (pMDI) formulations, (ii) a series of nonionic surfactants with methylene-based tails, and (iii) a series of nonionic surfactants with ether-based tails was investigated at the HFA134a|W interface using in situ tensiometry. This is the first time that the tension of the surfactant-modified HFA134a|W interface has been reported in the literature. The ether-based surfactants were shown to be very interfacially active, with tension decreasing by as much as 27 mN.m(-)(1). However, the methyl-based surfactants, including those from FDA-approved formulations, did not exhibit high activity at the HFA134a|W interface. These results are in direct agreement with the E(b) calculations. Significant differences in interfacial activity are noted for surfactants at the 2H,3H-perfluoropentane (HPFP)|water and HFA134a|W interfaces. Care should be taken, therefore, when results from the mimicking solvent (HPFP) are extrapolated to HFA134a-based systems. The results shown here are of relevance in the selection of surfactants capable of forming and stabilizing reverse aqueous aggregates in HFA-based pMDIs, which are promising formulations for the systemic delivery of biomolecules to and through the lungs
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|a Journal Article
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|a Research Support, U.S. Gov't, Non-P.H.S.
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|a Fluorocarbons
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|a Hydrocarbons, Fluorinated
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|a Surface-Active Agents
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|a Water
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|a 059QF0KO0R
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|a perfluoropentane
|2 NLM
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|a 678-26-2
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|a norflurane
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|a DH9E53K1Y8
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|a Peguin, Robson P S
|e verfasserin
|4 aut
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|a Chokshi, Udayan
|e verfasserin
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|a da Rocha, Sandro R P
|e verfasserin
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 22(2006), 21 vom: 10. Okt., Seite 8675-83
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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|g volume:22
|g year:2006
|g number:21
|g day:10
|g month:10
|g pages:8675-83
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