B cell reconstitution after rituximab treatment of lymphoma recapitulates B cell ontogeny

The long-term immunologic effects of B cell depletion with rituximab and the characteristics of the reconstituting B cell pool in lymphoma patients are not well defined, despite the widespread usage of this therapy. Here we report that during the B cell reconstitution phase a majority of the periphe...

Ausführliche Beschreibung

Bibliographische Detailangaben
Veröffentlicht in:	Clinical immunology (Orlando, Fla.). - 1999. - 122(2007), 2 vom: 15. Feb., Seite 139-45
1. Verfasser:	Anolik, Jennifer H (VerfasserIn)
Weitere Verfasser:	Friedberg, Jonathan W, Zheng, Bo, Barnard, Jennifer, Owen, Teresa, Cushing, Emily, Kelly, Jennifer, Milner, Eric C B, Fisher, Richard I, Sanz, Iñaki
Format:	Aufsatz
Sprache:	English
Veröffentlicht:	2007
Zugriff auf das übergeordnete Werk:	Clinical immunology (Orlando, Fla.)
Schlagworte:	Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Antibodies, Monoclonal Antibodies, Monoclonal, Murine-Derived Antineoplastic Agents Rituximab 4F4X42SYQ6

Beschreibung
Zusammenfassung:	The long-term immunologic effects of B cell depletion with rituximab and the characteristics of the reconstituting B cell pool in lymphoma patients are not well defined, despite the widespread usage of this therapy. Here we report that during the B cell reconstitution phase a majority of the peripheral blood B cells have an immature transitional phenotype (47.8%+/-25.2% vs. 4.4%+/-2.4% for normal controls, p<0.0001), similar to what has been described during the original ontogeny of the immune system and following bone marrow transplantation. Moreover, the recovery of the CD27+ memory B cell pool was delayed compared to normal B cell ontogeny, remaining below normal controls at 1 year post-rituximab (4.4%+/-3% vs. 31%+/-7%, p<0.0001). Expansion of functionally immature B cells and decreased memory B cells may contribute to an immunodeficient state in patients recovering from rituximab mediated B cell depletion, particularly with repeated treatment
Beschreibung:	Date Completed 07.03.2007 Date Revised 19.11.2015 published: Print-Electronic Citation Status MEDLINE
ISSN:	1521-7035