A non-seminomatous extra-gonadal germ cell tumor responding to intensive treatment : a case report

A 23-year-old man presented with lumbago as a chief complaint. Computed tomographic (CT) scan revealed multiple lung tumors, multiple liver tumors, bulky retroperitoneal tumors with marked elevation of serum lactic dehydrogenase (LDH), alpha-fetoprotein, and beta subunit of human chorionic gonadotro...

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Veröffentlicht in:Hinyokika kiyo. Acta urologica Japonica. - 1962. - 52(2006), 8 vom: 23. Aug., Seite 651-4
1. Verfasser: Harada, Akinori (VerfasserIn)
Weitere Verfasser: Yamamoto, Yasuyo, Taue, Ryuichi, Kishimoto, Tomoteru, Tanimoto, Shuji, Izaki, Hirofumi, Takahashi, Masayuki, Fukumori, Tomoharu, Nishitani, Masa-aki, Kanayama, Hiro-omi, Hayashi, Hideki
Format: Aufsatz
Sprache:Japanese
Veröffentlicht: 2006
Zugriff auf das übergeordnete Werk:Hinyokika kiyo. Acta urologica Japonica
Schlagworte:Case Reports English Abstract Journal Article Organoplatinum Compounds Bleomycin 11056-06-7 Etoposide 6PLQ3CP4P3 nedaplatin 8UQ3W6JXAN mehr... Paclitaxel P88XT4IS4D Cisplatin Q20Q21Q62J Ifosfamide UM20QQM95Y
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520 |a A 23-year-old man presented with lumbago as a chief complaint. Computed tomographic (CT) scan revealed multiple lung tumors, multiple liver tumors, bulky retroperitoneal tumors with marked elevation of serum lactic dehydrogenase (LDH), alpha-fetoprotein, and beta subunit of human chorionic gonadotropin (HCG-beta). The patient was referred to our hospital for treatment. Scrotal ultrasonography and physical examination revealed bilateral normal testes. Because of bulky retroperitoneal masses with elevated specific tumor markers as well as bilateral normal testes, our diagnosis led to extra-gonadal germ cell tumor. Because the pulmonary lesion had increased rapidly, chemotherapy was performed without the tumor biopsy. After multiple chemotherapy regimens including BEP (bleomycin, etoposide, cisplatin), high-dose chemotherapy, and TIN (paclitaxel, ifosfamide, nedaplatin), all tumor marker levels fell into within the normal range. The tumor size was decreased remarkably on CT. Then, retroperitoneal lymphadenectomy were performed to confirm whether they still contained viable tumor cells. They contained only necrotic tissues without viable cancer cells by pathological examination. Consequently, the patient has been free of recurrence for 18 months after intensive treatment 
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700 1 |a Taue, Ryuichi  |e verfasserin  |4 aut 
700 1 |a Kishimoto, Tomoteru  |e verfasserin  |4 aut 
700 1 |a Tanimoto, Shuji  |e verfasserin  |4 aut 
700 1 |a Izaki, Hirofumi  |e verfasserin  |4 aut 
700 1 |a Takahashi, Masayuki  |e verfasserin  |4 aut 
700 1 |a Fukumori, Tomoharu  |e verfasserin  |4 aut 
700 1 |a Nishitani, Masa-aki  |e verfasserin  |4 aut 
700 1 |a Kanayama, Hiro-omi  |e verfasserin  |4 aut 
700 1 |a Hayashi, Hideki  |e verfasserin  |4 aut 
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