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231223s2006 xx ||||| 00| ||eng c |
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|a pubmed25n0551.xml
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|a (DE-627)NLM165315954
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|a (NLM)16967415
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Mylonakis, Mathios E
|e verfasserin
|4 aut
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| 245 |
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|a Bone marrow mastocytosis in dogs with myelosuppressive monocytic ehrlichiosis (Ehrlichia canis)
|b a retrospective study
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| 264 |
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|c 2006
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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|a Band
|b nc
|2 rdacarrier
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|a Date Completed 09.11.2006
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|a Date Revised 10.11.2019
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|a published: Print
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|a Citation Status MEDLINE
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|a BACKGROUND: Bone marrow mastocytosis has been reported rarely in naturally occurring canine monocytic ehrlichiosis (CME)
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|a OBJECTIVES: The aims of the present study were to estimate the prevalence and magnitude of bone marrow mastocytosis in a case series of dogs with natural CME and to assess the association, if any, between mastocytosis and the clinical severity of the disease
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|a METHODS: Seventy-six dogs with confirmed CME (Ehrlichia canis) were included in the study. Affected dogs were allocated into group A (n = 51) without bone marrow hypoplasia and group B (n = 25) with bone marrow hypoplasia. Twenty clinically healthy Beagles not previously exposed to E canis served as controls (group C). The main inclusion criteria for group A were documentation of normocellular to hypercellular bone marrow and complete clinical cure following a 4-week treatment with doxycycline, while those for group B were bone marrow hypoplasia and lack of response to doxycycline. Bone marrow aspirate smears from all 96 dogs were Giemsa-stained and examined for the presence of mast cells, which were calculated as a percentage of 1,000 nucleated cells (NCs). The prevalence of mastocytosis was compared among the 3 groups by the Pearson's chi-square test
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|a RESULTS: Bone marrow mastocytosis (>0.1% of NCs) was found in 5 (20%) dogs in group B (range, 0.5-2.5% of NCs; median, 1% of NCs). One dog in each of groups A and C had 0.1% mast cells in the marrow. The prevalence of bone marrow mastocytosis in dogs in group B was significantly higher (P = .004) than in groups A and C
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|a CONCLUSION: Bone marrow mastocytosis can be seen in a substantial number of dogs with E canis-induced myelosuppression
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|a Journal Article
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|a Anti-Bacterial Agents
|2 NLM
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| 650 |
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|a Doxycycline
|2 NLM
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| 650 |
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7 |
|a N12000U13O
|2 NLM
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| 700 |
1 |
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|a Koutinas, Alex F
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Leontides, Leonidas S
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Veterinary clinical pathology
|d 1975
|g 35(2006), 3 vom: 08. Sept., Seite 311-4
|w (DE-627)NLM098159984
|x 0275-6382
|7 nnns
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| 773 |
1 |
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|g volume:35
|g year:2006
|g number:3
|g day:08
|g month:09
|g pages:311-4
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|a GBV_ILN_350
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| 951 |
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|a AR
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|d 35
|j 2006
|e 3
|b 08
|c 09
|h 311-4
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