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DE-627 |
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20250207124431.0 |
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231223s2006 xx ||||| 00| ||chi c |
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|a pubmed25n0549.xml
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|a (DE-627)NLM164570160
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|a (NLM)16887054
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a chi
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| 100 |
1 |
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|a Tan, Li-ping
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Expression and modulation of aquaporin 5 in hyperoxia induced lung injury
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| 264 |
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|c 2006
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 07.12.2010
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|a Date Revised 21.11.2013
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|a published: Print
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|a Citation Status MEDLINE
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| 520 |
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|a OBJECTIVE: To explore the expression and the modulation of aquaporin 5(AQP5) in hyperoxia induced lung injury
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|a METHODS: Sixty four Wistar rats of 2 weeks old, were randomly assigned to following groups (n=8): air group, hyperoxia 3, 7, 14 days groups, air + dexamethasone (Dex), hyperoxia 3, 7, 14 days + Dex groups. The rats were kept in oxygen chamber at normal pressure (O(2)> or =95%) in hyperoxia groups, and in normal pressure air (O(2)=21%) in room-air group, and the rats in Dex groups were injected with Dex (5 mg.kg(-1).d(-1)) intraperitoneally for 3 consecutive days in room-air or hyperoxia exposure. The expression of AQP5 mRNA level and the location were detected by reverse transcription-polymerase chain reaction and immunohistochemistry respectively
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|a RESULTS: AQP5 was strongly labeled in alveolar epithelial type I cells, and was also expressed in the secretory epithelium plasma membrane in the airway. The location of AQP5 in hyperoxia groups was not changed, but the expression of AQP5 mRNA had a notable gradual decline when the time of hyperoxia exposure was prolonged, compared to control group (all P<0.05). There was no difference in AQP5 mRNA level between hyperoxia groups and hyperoxia + Dex groups at different time points (all P<0.05)
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|a CONCLUSION: The significant decrease in AQP5 may be an important factor of pulmonary edema formation in hyperoxia-induced lung injury. Dex does not have effect on modulating the AQP5 expression in acute lung injury
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|a English Abstract
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|a Journal Article
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| 650 |
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|a Research Support, Non-U.S. Gov't
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| 650 |
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|a Aqp5 protein, rat
|2 NLM
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| 650 |
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|a Aquaporin 5
|2 NLM
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| 650 |
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|a RNA, Messenger
|2 NLM
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| 650 |
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|a Dexamethasone
|2 NLM
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| 650 |
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|a 7S5I7G3JQL
|2 NLM
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| 700 |
1 |
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|a Xu, Feng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kuang, Feng-wu
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
|d 1998
|g 18(2006), 8 vom: 04. Aug., Seite 462-5
|w (DE-627)NLM098227793
|x 1003-0603
|7 nnns
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| 773 |
1 |
8 |
|g volume:18
|g year:2006
|g number:8
|g day:04
|g month:08
|g pages:462-5
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|a GBV_USEFLAG_A
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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|d 18
|j 2006
|e 8
|b 04
|c 08
|h 462-5
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