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20250207111425.0 |
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231223s2006 xx ||||| 00| ||chi c |
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|a pubmed25n0547.xml
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|a (DE-627)NLM164041621
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|a (NLM)16831247
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a chi
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| 100 |
1 |
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|a Hong, Yong
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Dipyridamole preconditioning protects against ischemia/reperfusion injury of rat liver
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| 264 |
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|c 2006
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 07.12.2010
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|a Date Revised 21.11.2013
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|a published: Print
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|a Citation Status MEDLINE
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| 520 |
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|a OBJECTIVE: To investigate the protective mechanism of dipyridamole preconditioning against hepatic ischemia/reperfusion injury
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|a METHODS: Thirty SD rats were randomly divided into normal control group, ischemia/reperfusion group, and dipyridamole group, with 10 rats in each group. Using 45-minute ischemia/reperfusion rat model at normal temperature, 10 mg/kg of dipyridamole normal saline were injected into portal vein before ischemia. Only normal saline was injected in the ischemia/reperfusion group. An hour later, blood was obtained from the portal vein to determine the enzyme levels, including alanine aminotransferase (ALT) , lactate dehydrogenase (LDH) and tumor necrosis factor-alpha (TNF-alpha), and endothelin-1 (ET-1). The alteration in pathological morphology of the ischemia lobe was observed. The content of adenosine phosphates in the liver was determined
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|a RESULTS: The ALT and LDH activity, TNF-alpha, ET-1 levels were significantly higher in the ischemia/reperfusion group than those in the control group (all P<0.01). The levels of these variables were much lower in the dipyridamole group than those of the ischemia/reperfusion group (P<0.01), but little higher than those of the control group (P>0.05). The adenosine phosphates levels of ischemia/reperfusion group were significantly lower than those of the control group (P<0.01). They were much higher in the dipyridamole group than those of the ischemia/reperfusion group (P<0.01), but little higher than those of the control group (P>0.05). The control group had obvious alteration in pathological morphology, but only slight alteration was found in dipyridamole group, compared with control group
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|a CONCLUSION: Dipyridamole preconditioning protects against ischemia/reperfusion injury of the liver
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|a English Abstract
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| 650 |
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|a Journal Article
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| 650 |
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7 |
|a Dipyridamole
|2 NLM
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| 650 |
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7 |
|a 64ALC7F90C
|2 NLM
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| 700 |
1 |
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|a Liao, Wen-sheng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Mo, Rui-xiang
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
|d 1998
|g 18(2006), 7 vom: 10. Juli, Seite 425-7
|w (DE-627)NLM098227793
|x 1003-0603
|7 nnns
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| 773 |
1 |
8 |
|g volume:18
|g year:2006
|g number:7
|g day:10
|g month:07
|g pages:425-7
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|a GBV_ILN_350
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|a AR
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|d 18
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|e 7
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|c 07
|h 425-7
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