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20231223101635.0 |
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231223s2006 xx ||||| 00| ||eng c |
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|a pubmed24n0547.xml
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|a (NLM)16831007
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|a DE-627
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|e rakwb
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|a eng
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|a Vaccaro, Mauro
|e verfasserin
|4 aut
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|a Supramolecular aggregates of amphiphilic gadolinium complexes as blood pool MRI/MRA contrast agents
|b physicochemical characterization
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|c 2006
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|a Text
|b txt
|2 rdacontent
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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|a Band
|b nc
|2 rdacarrier
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|a Date Completed 16.08.2007
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|a Date Revised 24.11.2016
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|a published: Print
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|a Citation Status MEDLINE
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|a In this paper, we present the development of a new potential blood pool contrast agent for magnetic resonance imaging applications (MRA/MRI) based on gadolinium complexes containing amphiphilic supramolecular aggregates. A novel amphiphilic unimer, containing the DTPAGlu chelating agent covalently bound to two C18 alkylic chains, has been synthesized. DTPAGlu is a well-known chelating agent for a wide number of ions such as the paramagnetic metal ion Gd3+ used as contrast agent in MRA/MRI. The wide aggregation behavior of this surfactant, as free base or as gadolinium complex, has been studied and compared by means of dynamic light scattering, small-angle neutron scattering and cryogenic transmission electron microscopy techniques. Near neutral pH in both cases, the dominant aggregates are micelles. The high negative actual charge of the surfactant headgroup causes a strong headgroups repulsion, promoting the formation of large and high curvature aggregates. By decreasing pH and less markedly increasing the ionic strength, we observe a micelle-to-vesicle transition driven by a decreased electrostatic repulsion. A straightforward switch between different aggregation states can be particularly useful in the development of pH-responsive MRA/MRI contrast agents
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Contrast Media
|2 NLM
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|a Macromolecular Substances
|2 NLM
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|a Surface-Active Agents
|2 NLM
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|a Gadolinium DTPA
|2 NLM
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| 650 |
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|a K2I13DR72L
|2 NLM
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| 700 |
1 |
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|a Accardo, Antonella
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tesauro, Diego
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Mangiapia, Gaetano
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Löf, David
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Schillén, Karin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Söderman, Olle
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Morelli, Giancarlo
|e verfasserin
|4 aut
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| 700 |
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|a Paduano, Luigi
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 22(2006), 15 vom: 18. Juli, Seite 6635-43
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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|g volume:22
|g year:2006
|g number:15
|g day:18
|g month:07
|g pages:6635-43
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