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231223s2006 xx ||||| 00| ||eng c |
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|a pubmed24n0546.xml
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|a (NLM)16800694
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Barauskas, Justas
|e verfasserin
|4 aut
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| 245 |
1 |
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|a "Sponge" nanoparticle dispersions in aqueous mixtures of diglycerol monooleate, glycerol dioleate, and polysorbate 80
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| 264 |
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|c 2006
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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|a Band
|b nc
|2 rdacarrier
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|a Date Completed 03.08.2007
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|a Date Revised 24.11.2016
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|a published: Print
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|a Citation Status MEDLINE
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|a Lipid nanoparticles of nonlamellar lyotropic phases have a wide solubilizing and encapsulating spectrum for a range of substances thanks to their nanostructured interior featuring both lipophilic and hydrophilic domains. As a consequence, these systems have emerged as promising drug delivery systems in various pharmaceutical and diagnostic applications. Here we present the phase behavior and dispersion properties of a novel three-component lipid system composed of diglycerol monooleate (DGMO), glycerol dioleate (GDO), and polysorbate 80 (P80) which shows several advantageous features relating to drug delivery applications including: spontaneous dispersion formation with a narrow size distribution and tunable particle phase-structure. The obtained phase diagram shows the presence of lamellar (L(alpha)), hexagonal (H(2)), and reverse bicontinuous cubic (V(2)) liquid crystalline phases and an inverse micellar (L(2)) solution. A particularly interesting observation is the presence of a phase region where two liquid phases coexist, most likely the L(2) and L(3) ("sponge phase"). These two phase structures appear also to coexist in the submicron particles formed in the dilute water region, where the L(3) element appears to stabilize nanoparticles with inner L(2) structure. Increasing the fraction of the dispersing P80 component results in the growth of the more water rich L(3) "surface phase" at the expense of the size of the inner L(2) core
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Diglycerides
|2 NLM
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|a Micelles
|2 NLM
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|a Polysorbates
|2 NLM
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|a diolein
|2 NLM
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| 650 |
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7 |
|a Z3MP1W91CW
|2 NLM
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| 700 |
1 |
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|a Misiunas, Audrius
|e verfasserin
|4 aut
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| 700 |
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|a Gunnarsson, Torsten
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tiberg, Fredrik
|e verfasserin
|4 aut
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| 700 |
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|a Johnsson, Markus
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 22(2006), 14 vom: 04. Juli, Seite 6328-34
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
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|g volume:22
|g year:2006
|g number:14
|g day:04
|g month:07
|g pages:6328-34
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|h 6328-34
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