Involvement of the TNF-alpha autocrine-paracrine loop, via NF-kappaB and YY1, in the regulation of tumor cell resistance to Fas-induced apoptosis

Involvement of the TNF-alpha autocrine-paracrine loop, via NF-kappaB and YY1, in the regulation of tumor cell resistance to Fas-induced apoptosis

Many tumors are resistant to Fas ligand (FasL)-induced apoptosis. This study examined the role of tumor-derived TNF-alpha, via an autocrine/paracrine loop, in the regulation of tumor-cell resistance to FasL-induced apoptosis. We have reported that Fas expression and sensitivity to FasL is negatively...

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Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 120(2006), 3 vom: 19. Sept., Seite 297-309
1. Verfasser: Huerta-Yepez, Sara (VerfasserIn)
Weitere Verfasser: Vega, Mario, Garban, Hermes, Bonavida, Benjamin
Format: Aufsatz
Sprache:English
Veröffentlicht: 2006
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. BAY 11-7085 FASLG protein, human Fas Ligand Protein Membrane Glycoproteins NF-kappa B Nitriles mehr... RNA, Neoplasm Sulfones Tumor Necrosis Factor-alpha Tumor Necrosis Factors YY1 Transcription Factor YY1 protein, human fas Receptor CASP3 protein, human EC 3.4.22.- Caspase 3 Caspases