Comparison of effects of two kinds of fluid for resuscitation on bacterial translocation and inflammation of small intestine in rats with hemorrhagic shock

OBJECTIVE: To investigate the effects of Ringer's solution (RS) or 6% hydroxyethyl saline (HES) on bacterial translocation and inflammation of the small intestine in rats with hemorrhagic shock

Bibliographische Detailangaben
Veröffentlicht in:Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue. - 1998. - 18(2006), 3 vom: 09. März, Seite 146-9
1. Verfasser: Gao, Xin-yue (VerfasserIn)
Weitere Verfasser: Zhou, Qiang, Wu, Chang-yi, Pang, Qing-feng, Cao, Jun-li, Zeng, Yin-ming
Format: Aufsatz
Sprache:Chinese
Veröffentlicht: 2006
Zugriff auf das übergeordnete Werk:Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
Schlagworte:Comparative Study Journal Article Research Support, Non-U.S. Gov't Hydroxyethyl Starch Derivatives Isotonic Solutions Tumor Necrosis Factor-alpha Ringer's Solution 8026-10-6 Peroxidase EC 1.11.1.7
LEADER 01000caa a22002652 4500
001 NLM161153941
003 DE-627
005 20250207044728.0
007 tu
008 231223s2006 xx ||||| 00| ||chi c
028 5 2 |a pubmed25n0537.xml 
035 |a (DE-627)NLM161153941 
035 |a (NLM)16524504 
040 |a DE-627  |b ger  |c DE-627  |e rakwb 
041 |a chi 
100 1 |a Gao, Xin-yue  |e verfasserin  |4 aut 
245 1 0 |a Comparison of effects of two kinds of fluid for resuscitation on bacterial translocation and inflammation of small intestine in rats with hemorrhagic shock 
264 1 |c 2006 
336 |a Text  |b txt  |2 rdacontent 
337 |a ohne Hilfsmittel zu benutzen  |b n  |2 rdamedia 
338 |a Band  |b nc  |2 rdacarrier 
500 |a Date Completed 05.01.2010 
500 |a Date Revised 01.12.2018 
500 |a published: Print 
500 |a Citation Status MEDLINE 
520 |a OBJECTIVE: To investigate the effects of Ringer's solution (RS) or 6% hydroxyethyl saline (HES) on bacterial translocation and inflammation of the small intestine in rats with hemorrhagic shock 
520 |a METHODS: Fifty healthy male SD rats were randomly divided into the sham group (SHA group, n=10), the Ringer's solution group (RS group, n=20) and 6% hydroxyethyl saline group (HES group, n=20). Controlled hemorrhagic shock model was reproduced in RS and HES groups. Bacterial translocation to the liver, the content of tumor necrosis factor-alpha (TNF-alpha) in intestinal tissue, and the myeloperoxidase (MPO) activity in the intestinal tissue were determined and compared among the groups, and the pathologic changes in the small intestine were observed 
520 |a RESULTS: The mortality rate, bleeding volume and Chiu's scores were same in HES and RS groups (all P>0.05). Compared to SHA group, bacterial count and TNF-alpha level were increased significantly in HES and RS groups, and they were higher at 1 hour and lower at 24 hours in HES group than those in RS group. Compared to the SHA group, MPO activity increased at 1 hour in RS and HES groups, but no significant difference between the groups was found at 24 hours 
520 |a CONCLUSION: RS prevents compromise of the intestinal barrier function better than the HES at 1 hour after fluid resuscitation. However, HES seems to be better in protecting the intestinal barrier function compared with RS at 24 hours after fluid resuscitation 
650 4 |a Comparative Study 
650 4 |a Journal Article 
650 4 |a Research Support, Non-U.S. Gov't 
650 7 |a Hydroxyethyl Starch Derivatives  |2 NLM 
650 7 |a Isotonic Solutions  |2 NLM 
650 7 |a Tumor Necrosis Factor-alpha  |2 NLM 
650 7 |a Ringer's Solution  |2 NLM 
650 7 |a 8026-10-6  |2 NLM 
650 7 |a Peroxidase  |2 NLM 
650 7 |a EC 1.11.1.7  |2 NLM 
700 1 |a Zhou, Qiang  |e verfasserin  |4 aut 
700 1 |a Wu, Chang-yi  |e verfasserin  |4 aut 
700 1 |a Pang, Qing-feng  |e verfasserin  |4 aut 
700 1 |a Cao, Jun-li  |e verfasserin  |4 aut 
700 1 |a Zeng, Yin-ming  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue  |d 1998  |g 18(2006), 3 vom: 09. März, Seite 146-9  |w (DE-627)NLM098227793  |x 1003-0603  |7 nnns 
773 1 8 |g volume:18  |g year:2006  |g number:3  |g day:09  |g month:03  |g pages:146-9 
912 |a GBV_USEFLAG_A 
912 |a SYSFLAG_A 
912 |a GBV_NLM 
912 |a GBV_ILN_350 
951 |a AR 
952 |d 18  |j 2006  |e 3  |b 09  |c 03  |h 146-9