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01000caa a22002652 4500 |
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NLM161034187 |
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DE-627 |
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20250207042019.0 |
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tu |
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231223s2006 xx ||||| 00| ||eng c |
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|a pubmed25n0537.xml
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|a DE-627
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|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Bauer, Natali B
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Cerebrospinal fluid from a 6-year-old dog with severe neck pain
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| 264 |
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1 |
|c 2006
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|a Text
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|a ohne Hilfsmittel zu benutzen
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|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 05.05.2006
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| 500 |
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|a Date Revised 09.11.2019
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| 500 |
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|a published: Print
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|a Citation Status MEDLINE
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| 520 |
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|a A 6-year-old, intact female, Labrador Retriever/Terrier cross was presented to the University Veterinary Hospital, University College Dublin with a 3-week history of therapy-resistant cervical pain and intermittent fever. Physical examination findings included marked cervical pain resulting in neck extension and vocalization. Examination of the CSF revealed mild pleocytosis (total nucleated cells = 0.009 x 10(9)/L, reference interval <0.005 x 10(9)/L). Cytocentrifuged preparations of the CSF were of low cellularity, containing predominantly macrophages and occasional small lymphocytes. Several small- to medium-sized fragments of a slightly granular, amorphous, eosinophilic substance were observed. The majority of mononuclear cells were located within this material, in small groups of 3-13 cells. The amorphous foamy material stained positive with Luxol fast blue, suggestive of myelin-like material. The dog was euthanized and postmortem examination revealed intervertebral disk protrusion between C2 and C3. Hematoxylin- and Luxol fast blue-stained histopathologic sections of brain and spinal cord revealed only mild hemorrhage. The extracellular material in the CSF of this dog may have been caused by myelin degeneration or leakage of phospholipids from damaged cells. Because no histologic evidence of demyelination was observed with the disk extrusion, the myelin-like material in this case was thought to be the product of phospholipid breakdown from damaged cellular membranes. Three cases of dogs with spinal cord disease and myelin-like material in the CSF have been reported previously. The clinical significance of this finding is still unknown
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| 650 |
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4 |
|a Case Reports
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| 650 |
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4 |
|a Journal Article
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| 700 |
1 |
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|a Bassett, Hugh
|e verfasserin
|4 aut
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| 700 |
1 |
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|a O'Neill, Emma J
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Acke, Els
|e verfasserin
|4 aut
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| 773 |
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8 |
|i Enthalten in
|t Veterinary clinical pathology
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|g 35(2006), 1 vom: 01. März, Seite 123-5
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|x 0275-6382
|7 nnns
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| 773 |
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|g volume:35
|g year:2006
|g number:1
|g day:01
|g month:03
|g pages:123-5
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|d 35
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|h 123-5
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