Carbon-fiber microelectrodes modified with 4-sulfobenzene have increased sensitivity and selectivity for catecholamines

Elliptical and cylindrical geometries of carbon-fiber microelectrodes were modified by covalent attachment of 4-sulfobenzenediazonium tetrafluoroborate following its electroreduction. Elliptical electrodes fabricated from Thornel P-55 carbon fibers show the highest amount of 4-sulfobenzene attached...

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Veröffentlicht in:Langmuir : the ACS journal of surfaces and colloids. - 1992. - 22(2006), 5 vom: 28. Feb., Seite 1964-9
1. Verfasser: Hermans, Andre (VerfasserIn)
Weitere Verfasser: Seipel, Andrew T, Miller, Charles E, Wightman, R Mark
Format: Aufsatz
Sprache:English
Veröffentlicht: 2006
Zugriff auf das übergeordnete Werk:Langmuir : the ACS journal of surfaces and colloids
Schlagworte:Journal Article Research Support, N.I.H., Extramural Benzenesulfonates Catecholamines Diazonium Compounds Carbon 7440-44-0 Dopamine VTD58H1Z2X
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245 1 0 |a Carbon-fiber microelectrodes modified with 4-sulfobenzene have increased sensitivity and selectivity for catecholamines 
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520 |a Elliptical and cylindrical geometries of carbon-fiber microelectrodes were modified by covalent attachment of 4-sulfobenzenediazonium tetrafluoroborate following its electroreduction. Elliptical electrodes fabricated from Thornel P-55 carbon fibers show the highest amount of 4-sulfobenzene attached to the electrode. Fast-scan cyclic voltammetry was used to compare the response to dopamine and other neurochemicals at these modified carbon-fiber microelectrodes. The grafted layer causes an increased sensitivity to dopamine and other positively charged analytes that is due to increased adsorption of analyte in the grafted layer. However, this layer remains permeable to negatively charged compounds. Modified electrodes retain the increased sensitivity for dopamine during measurements in mouse brain tissue 
650 4 |a Journal Article 
650 4 |a Research Support, N.I.H., Extramural 
650 7 |a Benzenesulfonates  |2 NLM 
650 7 |a Catecholamines  |2 NLM 
650 7 |a Diazonium Compounds  |2 NLM 
650 7 |a Carbon  |2 NLM 
650 7 |a 7440-44-0  |2 NLM 
650 7 |a Dopamine  |2 NLM 
650 7 |a VTD58H1Z2X  |2 NLM 
700 1 |a Seipel, Andrew T  |e verfasserin  |4 aut 
700 1 |a Miller, Charles E  |e verfasserin  |4 aut 
700 1 |a Wightman, R Mark  |e verfasserin  |4 aut 
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