Constitutive and activation-inducible cyclooxygenase-2 expression enhances survival of chronic lymphocytic leukemia B cells

Constitutive and activation-inducible cyclooxygenase-2 expression enhances survival of chronic lymphocytic leukemia B cells

We recently reported that activated normal human B lymphocytes express Cox-2. These findings prompted us to evaluate whether human B-CLL cells express Cox-2 and synthesize prostaglandins. In contrast to naive human B cells, B-CLL cells constitutively expressed Cox-2 protein and produced PGE2, PGF2al...

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Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 120(2006), 1 vom: 15. Juli, Seite 76-90
1. Verfasser: Ryan, Elizabeth P (VerfasserIn)
Weitere Verfasser: Pollock, Stephen J, Kaur, Kuljeet, Felgar, Raymond E, Bernstein, Steven H, Chiorazzi, Nicholas, Phipps, Richard P
Format: Aufsatz
Sprache:English
Veröffentlicht: 2006
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't 3-(4-methylsulfonylphenyl)-4-phenyl-5-trifluoromethylisoxazole Cyclooxygenase 2 Inhibitors Immunoglobulin Heavy Chains Isoxazoles Nitrobenzenes Pyrazoles Sulfonamides mehr... Sulfones N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 123653-11-2 1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole 162054-19-5 Thromboxane A2 57576-52-0 Dinoprost B7IN85G1HY Cyclooxygenase 1 EC 1.14.99.1 Cyclooxygenase 2 Dinoprostone K7Q1JQR04M Indomethacin XXE1CET956