|
|
|
|
| LEADER |
01000naa a22002652 4500 |
| 001 |
NLM160469112 |
| 003 |
DE-627 |
| 005 |
20231223090149.0 |
| 007 |
tu |
| 008 |
231223s2006 xx ||||| 00| ||eng c |
| 028 |
5 |
2 |
|a pubmed24n0535.xml
|
| 035 |
|
|
|a (DE-627)NLM160469112
|
| 035 |
|
|
|a (NLM)16451828
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Waiser, Johannes
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Profibrotic cytokines and lymphocyte proliferation in stable renal allograft recipients treated with or without cyclosporine A
|
| 264 |
|
1 |
|c 2006
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
|
| 338 |
|
|
|a Band
|b nc
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 17.04.2006
|
| 500 |
|
|
|a Date Revised 03.12.2021
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a Profibrotic cytokines such as transforming growth factor-beta 1 (TGF-beta1) and endothelin-1 (ET-1) are involved in the pathogenesis of chronic allograft nephropathy. We assessed the effect of maintenance immunosuppression with or without cyclosporine A on TGF-beta1 and ET-1 expression as well as lymphocyte proliferation in renal allograft recipients. Patients were divided into groups according to their maintenance immunosuppression: A, azathioprine + methylprednisolone; B, cyclosporine A + azathioprine + methylprednisolone. TGF-beta1 and ET-1 plasma concentrations were not different between both groups. TGF-beta1 concentrations in cell culture supernatants and lymphocyte proliferation were higher in group B as compared to group A. No correlation was found between TGF-beta1 plasma concentrations and lymphocyte proliferation. Multiple linear regression analysis revealed that patient characteristics influence TGF-beta1 and ET-1 expression. In conclusion, plasma levels of profibrotic cytokines do not reflect the existing profibrotic potential of immunosuppressive drugs. Demographic factors and the employed co-medication confound the results
|
| 650 |
|
4 |
|a Clinical Trial
|
| 650 |
|
4 |
|a Comparative Study
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
7 |
|a Antibodies, Monoclonal
|2 NLM
|
| 650 |
|
7 |
|a CD3 Complex
|2 NLM
|
| 650 |
|
7 |
|a Cytokines
|2 NLM
|
| 650 |
|
7 |
|a Endothelin-1
|2 NLM
|
| 650 |
|
7 |
|a Immunosuppressive Agents
|2 NLM
|
| 650 |
|
7 |
|a TGFB1 protein, human
|2 NLM
|
| 650 |
|
7 |
|a Transforming Growth Factor beta
|2 NLM
|
| 650 |
|
7 |
|a Transforming Growth Factor beta1
|2 NLM
|
| 650 |
|
7 |
|a Cyclosporine
|2 NLM
|
| 650 |
|
7 |
|a 83HN0GTJ6D
|2 NLM
|
| 650 |
|
7 |
|a Azathioprine
|2 NLM
|
| 650 |
|
7 |
|a MRK240IY2L
|2 NLM
|
| 650 |
|
7 |
|a Creatine
|2 NLM
|
| 650 |
|
7 |
|a MU72812GK0
|2 NLM
|
| 650 |
|
7 |
|a Methylprednisolone
|2 NLM
|
| 650 |
|
7 |
|a X4W7ZR7023
|2 NLM
|
| 700 |
1 |
|
|a Schneider, Michael
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Eljazyfer, Sara
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Slowinski, Torsten
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Glander, Petra
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Einecke, Gunilla
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Budde, Klemens
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Neumayer, Hans-Hellmut
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Böhler, Torsten
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 119(2006), 1 vom: 07. Apr., Seite 59-66
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
|
| 773 |
1 |
8 |
|g volume:119
|g year:2006
|g number:1
|g day:07
|g month:04
|g pages:59-66
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_11
|
| 912 |
|
|
|a GBV_ILN_24
|
| 912 |
|
|
|a GBV_ILN_350
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 119
|j 2006
|e 1
|b 07
|c 04
|h 59-66
|