Membrane-mimetic films of asymmetric phosphatidylcholine lipid bolaamphiphiles

Membrane-spanning phospholipid bolaamphiphiles either alone or as a constituent of a multicomponent lipid membrane may prove to be facile building blocks for generating robust bioactive membrane-mimetic assemblies. We have previously reported the synthesis of asymmetric dialkyl phospholipid bolaamph...

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Veröffentlicht in:Langmuir : the ACS journal of surfaces and colloids. - 1992. - 22(2006), 3 vom: 31. Jan., Seite 1201-8
1. Verfasser: Sun, Xue-Long (VerfasserIn)
Weitere Verfasser: Biswas, Nilanjana, Kai, Toshitsugu, Dai, Zhifei, Dluhy, Richard A, Chaikof, Elliot L
Format: Aufsatz
Sprache:English
Veröffentlicht: 2006
Zugriff auf das übergeordnete Werk:Langmuir : the ACS journal of surfaces and colloids
Schlagworte:Journal Article Research Support, N.I.H., Extramural Phosphatidylcholines Water 059QF0KO0R
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520 |a Membrane-spanning phospholipid bolaamphiphiles either alone or as a constituent of a multicomponent lipid membrane may prove to be facile building blocks for generating robust bioactive membrane-mimetic assemblies. We have previously reported the synthesis of asymmetric dialkyl phospholipid bolaamphiphiles that contain ester linked phosphatidylcholine and amine functionalities at opposite chain ends. In this report, we describe the synthesis of phospholipid bolaamphiphiles that are conjugated to biotin via the terminal amine with or without a poly(ethylene oxide) spacer arm of varying chain length. The behavior of biotinylated bolaamphiphiles as a self-assembled monolayer at an air-water interface was characterized by epi-fluorescence microscopy and revealed that domain structure and pi-A isotherms were substantially influenced by linker type and size. Substrate bound assemblies were produced by Langmuir-Blodgett deposition onto planar substrates coated with an avidin derivatized polyelectrolyte multilayer. Significantly, external reflectance infrared spectroscopy confirmed the fabrication of bolaamphiphile thin films that display extended stability in vitro 
650 4 |a Journal Article 
650 4 |a Research Support, N.I.H., Extramural 
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700 1 |a Biswas, Nilanjana  |e verfasserin  |4 aut 
700 1 |a Kai, Toshitsugu  |e verfasserin  |4 aut 
700 1 |a Dai, Zhifei  |e verfasserin  |4 aut 
700 1 |a Dluhy, Richard A  |e verfasserin  |4 aut 
700 1 |a Chaikof, Elliot L  |e verfasserin  |4 aut 
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