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231223s2006 xx ||||| 00| ||eng c |
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|a pubmed24n0534.xml
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|a (DE-627)NLM160269679
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|a (NLM)16430282
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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|a Nakahara, Hiromichi
|e verfasserin
|4 aut
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|a Mode of interaction of amphiphilic alpha-helical peptide with phosphatidylcholines at the air-water interface
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|c 2006
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|a Text
|b txt
|2 rdacontent
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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|a Band
|b nc
|2 rdacarrier
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|a Date Completed 01.05.2007
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|a Date Revised 21.11.2013
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|a published: Print
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|a Citation Status MEDLINE
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|a Surface pressure (pi)-, surface potential (deltaV)-, and dipole moment (mu(perpendicular))-area (A) isotherms and morphological behavior were examined for monolayers of a newly designed 18-mer amphiphilic alpha-helical peptide (Hel 13-5), DPPC, and DPPC/egg-PC (1:1) and their combinations by the Wilhelmy method, ionizing electrode method, fluorescence microscopy (FM), and atomic force microscopy (AFM). The newly designed Hel 13-5 showed rapid adsorption into the air-liquid interface to form interfacial films such as a SP-B function. Regardless of the composition and constituents in their multicomponent system of DPPC/egg-PC, the collapse pressure (pi(c); approximately 42 mN m(-1)) was constant, implying that Hel 13-5 with the fluid composition of egg-PC is squeezed out of Hel 13-5/DPPC/egg-PC monolayers accompanying a two- to three-dimensional phase transformation. FM showed that adding a small amount of Hel 13-5 to DPPC induced a dispersed pattern of ordered domains with a "moth-eaten" appearance, whereas shrinkage of ordered domains in size occurred for the DPPC/egg-PC mixture with Hel 13-5. Furthermore, AFM indicated that (i) the intermediate phase was formed in pure Hel 13-5 systems between monolayer states and excluded nanoparticles, (ii) protrusions necessarily located on DPPC monolayers, and (iii) beyond the collapse pressure of Hel 13-5, Hel 13-5 was squeezed out of the system into the aqueous subphase. Furthermore, hysteresis curves of these systems nicely resemble those of the DPPC/SP-B and DPPC/SP-C mixtures reported before
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Peptides
|2 NLM
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|a Phosphatidylcholines
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|a Water
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|a 059QF0KO0R
|2 NLM
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| 700 |
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|a Nakamura, Shohei
|e verfasserin
|4 aut
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|a Hiranita, Takato
|e verfasserin
|4 aut
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| 700 |
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|a Kawasaki, Hideya
|e verfasserin
|4 aut
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| 700 |
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|a Lee, Sannamu
|e verfasserin
|4 aut
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|a Sugihara, Gohsuke
|e verfasserin
|4 aut
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|a Shibata, Osamu
|e verfasserin
|4 aut
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1999
|g 22(2006), 3 vom: 31. Jan., Seite 1182-92
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
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|g volume:22
|g year:2006
|g number:3
|g day:31
|g month:01
|g pages:1182-92
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