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01000naa a22002652 4500 |
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NLM160269393 |
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DE-627 |
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20231223085755.0 |
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231223s2006 xx ||||| 00| ||eng c |
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|a pubmed24n0534.xml
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|a (DE-627)NLM160269393
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|a (NLM)16430254
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Säily, V Matti J
|e verfasserin
|4 aut
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| 245 |
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|a Impact of reductive cleavage of an intramolecular disulfide bond containing cationic gemini surfactant in monolayers and bilayers
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| 264 |
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|c 2006
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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|a Date Completed 01.05.2007
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|a Date Revised 24.01.2006
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|a published: Print
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|a Citation Status MEDLINE
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|a The properties of a novel disulfide-bond-containing gemini surfactant bis[N,N-dimethyl-N-hexadecyl-N-(2-mercaptoethyl)ammonium bromide] disulfide (DSP) were studied using a Langmuir balance, supported monolayers, differential scanning calorimetry, giant vesicles, and LUVs. In 150 mM NaCl the cmc for DSP was 7.5 microM whereas that of the monomer N,N-dimethyl-N-hexadecyl-N-(2-mercaptoethyl)ammonium bromide (MSP) was 12.1 microM. Both surfactants exhibited single endotherms upon DSC, with peak temperatures Tm at 21.7 and 20.1 degrees C for DSP and MSP, respectively. The endotherm for MSP was significantly broader indicating less cooperative melting. Both in monolayers and in vesicles reductive cleavage of the disulfide bond of DSP could be obtained by glutathione (GSH). For Langmuir films of DSP the addition of GSH into the subphase led to a decrease in surface pressure pi as well as surface dipole potential psi. Although the cleavage by GSH was significantly slower in the presence of a charge saturating concentration of DNA, it did not prevent the reaction. The resulting monomers detached from supported monolayers, leading to loss of affinity of the surface for DNA. Disruption of giant vesicles containing DSP within approximately 30 s following a local injection of GSH was observed, revealing membrane destabilization
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Disulfides
|2 NLM
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|a Surface-Active Agents
|2 NLM
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1 |
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|a Ryhänen, Samppa J
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lankinen, Hilkka
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Luciani, Paola
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Mancini, Giovanna
|e verfasserin
|4 aut
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|a Parry, Mikko J
|e verfasserin
|4 aut
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|a Kinnunen, Paavo K J
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 22(2006), 3 vom: 31. Jan., Seite 956-62
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
1 |
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|g volume:22
|g year:2006
|g number:3
|g day:31
|g month:01
|g pages:956-62
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|d 22
|j 2006
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|c 01
|h 956-62
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