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01000naa a22002652 4500 |
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NLM160110319 |
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DE-627 |
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20231223085441.0 |
| 007 |
tu |
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231223s2006 xx ||||| 00| ||eng c |
| 028 |
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2 |
|a pubmed24n0534.xml
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|a (DE-627)NLM160110319
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|a (NLM)16413227
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Kim, Soon Ha
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a STAT4/6-dependent differential regulation of chemokine receptors
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| 264 |
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1 |
|c 2006
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 30.03.2006
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| 500 |
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|a Date Revised 15.11.2006
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| 500 |
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|a published: Print-Electronic
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| 500 |
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|a Citation Status MEDLINE
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| 520 |
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|a The major cell fate decision of the CD4+ helper T cells is the development of Th1 and Th2 phenotype, the balance of which determines the outcome of a wide variety of autoimmune responses. Signal transducers and activators of transcription (STATs), in particular STAT4 and STAT6, are essential for the development of Th1 and Th2 cells, respectively. We used Balb/c mice lacking STAT4 or STAT6 to explore the ability of helper T cells to express chemokine receptors. We demonstrated that both STAT4-/- and STAT6-/- CD4+ lymphocytes showed impaired expansion as well as differentiation into IFN-gamma-secreting Th1 cells and IL2-, IL4-, IL10-secreting Th2 cells. Interestingly, the expression of chemokine receptors, which is STAT4/6-dependent, was differentially regulated via two distinct mechanisms, positively (CCR3, CCR4) and negatively (CCR5, CCR7). These results provide the basis for STAT-dependent differential regulation of chemokine receptors in Th subsets
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| 650 |
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4 |
|a Comparative Study
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| 650 |
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4 |
|a Journal Article
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| 650 |
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7 |
|a Receptors, Chemokine
|2 NLM
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| 650 |
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7 |
|a STAT4 Transcription Factor
|2 NLM
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| 650 |
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7 |
|a STAT6 Transcription Factor
|2 NLM
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| 650 |
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7 |
|a Stat4 protein, mouse
|2 NLM
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| 650 |
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7 |
|a Stat6 protein, mouse
|2 NLM
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| 700 |
1 |
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|a Gunst, Kurt V
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sarvetnick, N
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 118(2006), 2-3 vom: 27. Feb., Seite 250-7
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:118
|g year:2006
|g number:2-3
|g day:27
|g month:02
|g pages:250-7
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 118
|j 2006
|e 2-3
|b 27
|c 02
|h 250-7
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