Delivering PD-1 inhibitory signal concomitant with blocking ICOS co-stimulation suppresses lupus-like syndrome in autoimmune BXSB mice

Delivering PD-1 inhibitory signal concomitant with blocking ICOS co-stimulation suppresses lupus-like syndrome in autoimmune BXSB mice

BXSB mice spontaneously develop an autoimmune syndrome characterized by hypergammaglobulinemia, autoantibody production, and the development of fatal glomerulonephritis that closely resembles systemic lupus erythematosus (SLE) in humans. While blocking positive T cell co-stimulation has shown effect...

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Détails bibliographiques
Publié dans:Clinical immunology (Orlando, Fla.). - 1999. - 118(2006), 2-3 vom: 02. Feb., Seite 258-67
Auteur principal: Ding, Hanlu (Auteur)
Autres auteurs: Wu, Xiongfei, Wu, Jun, Yagita, Hideo, He, Yani, Zhang, Jianguo, Ren, Jiangwen, Gao, Wenda
Format: Article
Langue:English
Publié: 2006
Accès à la collection:Clinical immunology (Orlando, Fla.)
Sujets:Journal Article Research Support, Non-U.S. Gov't Antigens, Differentiation Antigens, Differentiation, T-Lymphocyte ICOS protein, human Icos protein, mouse Icosl protein, mouse Immunoglobulin G Inducible T-Cell Co-Stimulator Ligand Inducible T-Cell Co-Stimulator Protein plus... Pdcd1 protein, mouse Programmed Cell Death 1 Receptor Proteins DNA 9007-49-2