Prospective 2-year clinical study of patients with positive IgG-antibodies after recovering from severe acute respiratory syndrome

OBJECTIVE: To investigate the clinical characteristics of patients recovering from severe acute respiratory syndrome (SARS) during 2 years after the infection

Bibliographische Detailangaben
Veröffentlicht in:Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue. - 1998. - 17(2005), 12 vom: 16. Dez., Seite 740-2
1. Verfasser: Yin, Cheng-hong (VerfasserIn)
Weitere Verfasser: Wang, Chao, Wen, Yan, Jiang, Li, Lu, Qin, Li, Jing-ling, Wang, Jing, He, Zheng-yi, Zhang, Shu-wen, Wang, Bao-en
Format: Aufsatz
Sprache:Chinese
Veröffentlicht: 2005
Zugriff auf das übergeordnete Werk:Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
Schlagworte:English Abstract Journal Article Research Support, Non-U.S. Gov't Antibodies, Viral Immunoglobulin G
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245 1 0 |a Prospective 2-year clinical study of patients with positive IgG-antibodies after recovering from severe acute respiratory syndrome 
264 1 |c 2005 
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500 |a Date Completed 05.01.2010 
500 |a Date Revised 02.01.2006 
500 |a published: Print 
500 |a Citation Status MEDLINE 
520 |a OBJECTIVE: To investigate the clinical characteristics of patients recovering from severe acute respiratory syndrome (SARS) during 2 years after the infection 
520 |a METHODS: The antibody of SARS-IgG, T cell subsets, chest CT, and the pulmonary function were observed in patients 1 month, 3 months, 6 months, and 2 years after convalescence from SARS 
520 |a RESULTS: In the 20 SARS cases, the level of antibodies was found to descend gradually and slowly during 2 years after convalescence. In the majority of patients T cell subsets recovered completely to normal range at the second examination. At the first re-examination, the rate of abnormal chest CT was 65%, and the main abnormal images included ground glass opacities, thickening of inter-lobular and intra-lobular septa, distorted lobular structure, thickened bronchovascular bundles, thickened pleura, arc shadow under the pleura, bronchiolar dilation, and honey comb like shadows. The rate of abnormal chest CT was 30% at the 4 fourth examination. At the first re-examination, the abnormal rate of KCO was highest, accompanied by abnormalities of forced expiratory volume in 1 second (FEV1) and the diffusing capacity of the lung for carbon monoxide (DLCO), and it began to recover since the third examination 
520 |a CONCLUSION: The level of SARS-IgG descends slowly, and it may last for a long time. The recovery of chest CT to normal may take a long time. The abnormality in pulmonary functions manifests mainly as impairment of diffusion function. Further research on SARS is necessary 
650 4 |a English Abstract 
650 4 |a Journal Article 
650 4 |a Research Support, Non-U.S. Gov't 
650 7 |a Antibodies, Viral  |2 NLM 
650 7 |a Immunoglobulin G  |2 NLM 
700 1 |a Wang, Chao  |e verfasserin  |4 aut 
700 1 |a Wen, Yan  |e verfasserin  |4 aut 
700 1 |a Jiang, Li  |e verfasserin  |4 aut 
700 1 |a Lu, Qin  |e verfasserin  |4 aut 
700 1 |a Li, Jing-ling  |e verfasserin  |4 aut 
700 1 |a Wang, Jing  |e verfasserin  |4 aut 
700 1 |a He, Zheng-yi  |e verfasserin  |4 aut 
700 1 |a Zhang, Shu-wen  |e verfasserin  |4 aut 
700 1 |a Wang, Bao-en  |e verfasserin  |4 aut 
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