Altered collagen II peptides inhibited T-cell activation in rheumatoid arthritis

It has been reported that collagen II (CII)-derived peptide induced T-cell activation via its amino acids responsible for T-cell receptor (TCR) recognition. In this study, three altered CII263-272 peptide ligands (APL) containing multiple substitutions of TCR contact residues were synthesized. Their...

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Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 118(2006), 2-3 vom: 15. Feb., Seite 317-23
1. Verfasser: Li, Ru (VerfasserIn)
Weitere Verfasser: Li, Xia, Li, Zhanguo
Format: Aufsatz
Sprache:English
Veröffentlicht: 2006
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Antigens, CD Antigens, Differentiation, T-Lymphocyte CD69 antigen Collagen Type II Cytokines HLA-DR4 Antigen Immunosuppressive Agents Lectins, C-Type mehr... Ligands Peptide Fragments Receptors, Antigen, T-Cell Receptors, Interleukin-2