Genetic analysis and functional evaluation of the C/T(-318) and A/G(-1661) polymorphisms of the CTLA-4 gene in patients affected with Graves' disease

Genetic analysis and functional evaluation of the C/T(-318) and A/G(-1661) polymorphisms of the CTLA-4 gene in patients affected with Graves' disease

In this study, we evaluated the A/G(-1661), C/T(-318), A/G49 and A/G6230 single nucleotide polymorphisms (SNPs) of the cytotoxic T lymphocyte antigen 4 (CTLA-4) gene for association with Graves' disease (GD) in 126 Russian simplex families. The conditional TDT analysis revealed significant over...

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Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 118(2006), 2-3 vom: 03. Feb., Seite 233-42
1. Verfasser: Chistiakov, Dimitry A (VerfasserIn)
Weitere Verfasser: Savost'anov, Kirill V, Turakulov, Rustam I, Efremov, Ilya A, Demurov, Lev M
Format: Aufsatz
Sprache:English
Veröffentlicht: 2006
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Antigens, CD Antigens, Differentiation CTLA-4 Antigen CTLA4 protein, human LEF1 protein, human Lymphoid Enhancer-Binding Factor 1 MADS Domain Proteins MEF2 Transcription Factors mehr... MEF2D protein, human Myogenic Regulatory Factors