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231223s2005 xx ||||| 00| ||chi c |
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|a pubmed25n0530.xml
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|a (DE-627)NLM159024676
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|a (NLM)16297318
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a chi
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| 100 |
1 |
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|a Wang, Xue-min
|e verfasserin
|4 aut
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|a Effects of moderate hypothermia on expression of nuclear factor-KappaB in rats with acute pancreatitis
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|c 2005
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|a Text
|b txt
|2 rdacontent
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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|a Date Completed 05.01.2010
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|a Date Revised 21.11.2005
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|a published: Print
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|a Citation Status MEDLINE
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|a OBJECTIVE: To observe the dynamic changes in the DNA binding activity of nuclear factor-KappaB (NF-KappaB) in rat pancreatic and lung tissues in acute hemorrhagic necrotizing pancreatitis (AHNP), and investigate the effects of moderate hypothermia on AHNP-induced NF-KappaB binding activity in a time-dependent fashion
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|a METHODS: A group of 24 rats was randomly divided into control group, 2, 5 or 12 hours groups after reproduction of AHNP. NF-KappaB binding activity in pancreas and lung tissues was determined using electrophoretic mobility shift assay (EMSA). In another group of 36 rats were randomized into three groups with equal number: sham-operated rats which were kept under 37-37.5 degrees C after laparotomy; AHNP rats with normothermia (37-37.5 degrees C); AHNP rats with moderate hypothermia (32-33 degrees C). Activity of NF-KappaB was assessed at 2 or 5 hours after reproduction of pancreatitis
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|a RESULTS: DNA binding activity of NF-KappaB in pancreas and lung tissue of AHNP rats gradually increased after the development of pancreatitis, and NF-KappaB binding activity was more prominent in pancreas than that in lung tissue at each time point (all P<0.01). NF-KappaB binding activity was inhibited at 2 and 5 hours of moderate hypothermia in lung tissue (P<0.01), but there was no difference in pancreatic tissue between normothermic and hypothermic rats at each time point
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|a CONCLUSION: These data suggest that the expression of NF-KappaB is significantly increased after the development of AHNP. Moderate hypothermia could inhibit the expression of NF-KappaB in lung tissue in acute pancreatitis
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|a English Abstract
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a NF-kappa B
|2 NLM
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| 700 |
1 |
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|a Jiang, Wei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhou, Ming
|e verfasserin
|4 aut
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| 700 |
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|a Zhao, Gang
|e verfasserin
|4 aut
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| 700 |
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|a Hang, Yan-nan
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
|d 1998
|g 17(2005), 11 vom: 19. Nov., Seite 658-61
|w (DE-627)NLM098227793
|x 1003-0603
|7 nnns
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| 773 |
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|g volume:17
|g year:2005
|g number:11
|g day:19
|g month:11
|g pages:658-61
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|a SYSFLAG_A
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|a GBV_NLM
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|a GBV_ILN_350
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|a AR
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|d 17
|j 2005
|e 11
|b 19
|c 11
|h 658-61
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