Deaggregation behavior of the phenol gemini derivatives

The phenol gemini compounds were synthesized by rebuilding the substituents and lateral chain on the phenyl ring. Two parts of the molecules were connected by a spacer of hydrocarbon chain via ester groups. The deaggregation behaviors of target molecules were investigated by studying coaggregation b...

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Veröffentlicht in:Langmuir : the ACS journal of surfaces and colloids. - 1992. - 21(2005), 24 vom: 22. Nov., Seite 10931-40
1. Verfasser: Chen, Jian (VerfasserIn)
Weitere Verfasser: Yang, Fan, Ji, Guo-Zhen, Yang, Hui, Shen, Zheng-Wu, Zhou, Xiu-Jia
Format: Aufsatz
Sprache:English
Veröffentlicht: 2005
Zugriff auf das übergeordnete Werk:Langmuir : the ACS journal of surfaces and colloids
Schlagworte:Journal Article
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520 |a The phenol gemini compounds were synthesized by rebuilding the substituents and lateral chain on the phenyl ring. Two parts of the molecules were connected by a spacer of hydrocarbon chain via ester groups. The deaggregation behaviors of target molecules were investigated by studying coaggregation behaviors, evaluating the deaggregating abilities in terms of fluorescence measurements, the measurements of their aggregation number and the effects on restraining the cell adhesion. In present cases, all of these experiments give the same results; that is, in these molecules, the longer branched methyl hydrocarbon chain and the combination of methoxy with hydroxyl groups on the phenyl ring possess the higher deaggregating abilities in the studied situation. The molecules with two hydrocarbon chains, i.e., the phenol gemini compounds, are more effective to deaggregate the aggregated probes than the molecules with one hydrocarbon chain. To find an effective deaggregator might be helpful to design the medicine for the cure of arteriosclerosis 
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700 1 |a Yang, Fan  |e verfasserin  |4 aut 
700 1 |a Ji, Guo-Zhen  |e verfasserin  |4 aut 
700 1 |a Yang, Hui  |e verfasserin  |4 aut 
700 1 |a Shen, Zheng-Wu  |e verfasserin  |4 aut 
700 1 |a Zhou, Xiu-Jia  |e verfasserin  |4 aut 
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