Oxidative stress in the erythrocytes of cattle intoxicated with Senecio sp
BACKGROUND: Intoxication caused by Senecio sp is characterized by irreversible damage to liver cells and may be associated with oxidative stress
| Veröffentlicht in: | Veterinary clinical pathology. - 1975. - 34(2005), 4 vom: 03. Dez., Seite 353-7 |
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| 1. Verfasser: | |
| Weitere Verfasser: | , , , , |
| Format: | Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
2005
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| Zugriff auf das übergeordnete Werk: | Veterinary clinical pathology |
| Schlagworte: | Journal Article Antioxidants Sulfhydryl Compounds Thiobarbituric Acid Reactive Substances Copper 789U1901C5 Superoxide Dismutase EC 1.15.1.1 Zinc J41CSQ7QDS |
| Zusammenfassung: | BACKGROUND: Intoxication caused by Senecio sp is characterized by irreversible damage to liver cells and may be associated with oxidative stress OBJECTIVES: The aim of this study was to evaluate the effects of intoxication by Senecio sp on lipoperoxidation, antioxidant defenses, and the osmotic resistance of erythrocytes in cattle METHODS: Blood samples from 30 intoxicated animals (group 1) and 30 healthy animals (group 2) were analyzed. The diagnosis of poisoning by Senecio sp was based on histopathologic lesions verified through hepatic biopsy. The following biochemical parameters of oxidative stress in the erythrocytes were determined: thiobarbituric acid-reactive substances (TBARS), copper-zinc superoxide dismutase (CuZnSOD) activity, and nonprotein sulfhydryl (NPSH) groups. Erythrocyte osmotic fragility also was evaluated RESULTS: TBARS concentration and CuZnSOD activity were significantly (P <.001) higher in group 1 when compared with group 2. The concentration of erythrocyte NPSH groups was significantly (P <.03) lower in group 1 when compared with group 2. Osmotic fragility was more pronounced in the erythrocytes of group 1 when compared with group 2 (P < .001) CONCLUSIONS: The results of this study indicate that poisoning by Senecio sp causes an increase in lipoperoxidation, oxidation of NPSH groups, and consequently, oxidative stress in bovine erythrocytes that may contribute to hemolysis. These findings may contribute to a better understanding of the mechanisms involved in cell damage in animals intoxicated by Senecio sp |
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| Beschreibung: | Date Completed 06.01.2006 Date Revised 09.11.2019 published: Print ErratumIn: Vet Clin Pathol. 2006 Mar;35(1):110 Citation Status MEDLINE |
| ISSN: | 0275-6382 |