Synthesis of monodisperse biodegradable microgels in microfluidic devices

Microgels are promising materials in drug delivery and biomedicine. Although monodisperse microgels would offer considerable advantages, most microgels investigated and used today are polydisperse in size. We report on the fabrication of 10 mum sized monodisperse microgels by emulsifying an aqueous...

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Veröffentlicht in:Langmuir : the ACS journal of surfaces and colloids. - 1991. - 21(2005), 23 vom: 08. Nov., Seite 10275-9
1. Verfasser: De Geest, Bruno G (VerfasserIn)
Weitere Verfasser: Urbanski, John Paul, Thorsen, Todd, Demeester, Jo, De Smedt, Stefaan C
Format: Aufsatz
Sprache:English
Veröffentlicht: 2005
Zugriff auf das übergeordnete Werk:Langmuir : the ACS journal of surfaces and colloids
Schlagworte:Letter Research Support, Non-U.S. Gov't Biocompatible Materials Gels Methacrylates hydroxyethyl methacrylate 6E1I4IV47V
Beschreibung
Zusammenfassung:Microgels are promising materials in drug delivery and biomedicine. Although monodisperse microgels would offer considerable advantages, most microgels investigated and used today are polydisperse in size. We report on the fabrication of 10 mum sized monodisperse microgels by emulsifying an aqueous dextran-hydroxyethyl methacrylate (dex-HEMA) phase within an oil phase at the junction of microfluidic channels. Dex-HEMA microgels are biodegradable and are ideally suited for the controlled delivery of proteins
Beschreibung:Date Completed 04.05.2007
Date Revised 15.11.2012
published: Print
Citation Status MEDLINE
ISSN:0743-7463