Clinical link between MHC class II haplotype and interferon-beta (IFN-beta) immunogenicity

Clinical link between MHC class II haplotype and interferon-beta (IFN-beta) immunogenicity

Interferon-beta (IFN-beta) is currently the first-line therapy for the treatment of multiple sclerosis (MS). However, a significant percentage of MS patients develop anti-IFN-beta antibodies, which can reduce the efficacy of the drug. We describe an association between a common MHC class II allele (...

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Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 118(2006), 1 vom: 07. Jan., Seite 42-50
1. Verfasser: Barbosa, Maria D F S (VerfasserIn)
Weitere Verfasser: Vielmetter, Jost, Chu, Seung, Smith, David D, Jacinto, Jonathan
Format: Aufsatz
Sprache:English
Veröffentlicht: 2006
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, U.S. Gov't, Non-P.H.S. Antibodies HLA-DQ Antigens HLA-DQ alpha-Chains HLA-DQ beta-Chains HLA-DQA1 antigen HLA-DQB1 antigen HLA-DR Antigens HLA-DRB1 Chains mehr... HLA-DRB1*07 antigen Interferon beta-1b 145155-23-3 Interferon-beta 77238-31-4