Amelioration of SLE-like manifestations in (NZBxNZW)F1 mice following treatment with a peptide based on the complementarity determining region 1 of an autoantibody is associated with a down-regulation of apoptosis and of the pro-apoptotic factor JNK kinase
Treatment with peptides based on the complementarity determining regions (CDR) of murine and human monoclonal anti-DNA antibodies that bear the common idiotype, 16/6 Id, ameliorates disease manifestations of mice with either induced or spontaneous SLE. Aberrant expression and function of the p21Ras/...
Veröffentlicht in: | Clinical immunology (Orlando, Fla.). - 1999. - 117(2005), 3 vom: 15. Dez., Seite 262-70 |
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1. Verfasser: | |
Weitere Verfasser: | , , , , , |
Format: | Aufsatz |
Sprache: | English |
Veröffentlicht: |
2005
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Zugriff auf das übergeordnete Werk: | Clinical immunology (Orlando, Fla.) |
Schlagworte: | Journal Article Research Support, Non-U.S. Gov't Autoantibodies Complementarity Determining Regions Peptide Fragments MAP Kinase Kinase 4 EC 2.7.12.2 Proto-Oncogene Proteins p21(ras) EC 3.6.5.2 |