Amelioration of SLE-like manifestations in (NZBxNZW)F1 mice following treatment with a peptide based on the complementarity determining region 1 of an autoantibody is associated with a down-regulation of apoptosis and of the pro-apoptotic factor JNK kinase

Amelioration of SLE-like manifestations in (NZBxNZW)F1 mice following treatment with a peptide based on the complementarity determining region 1 of an autoantibody is associated with a down-regulation of apoptosis and of the pro-apoptotic factor JNK kinase

Treatment with peptides based on the complementarity determining regions (CDR) of murine and human monoclonal anti-DNA antibodies that bear the common idiotype, 16/6 Id, ameliorates disease manifestations of mice with either induced or spontaneous SLE. Aberrant expression and function of the p21Ras/...

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Publié dans:Clinical immunology (Orlando, Fla.). - 1999. - 117(2005), 3 vom: 15. Dez., Seite 262-70
Auteur principal: Rapoport, Micha J (Auteur)
Autres auteurs: Sharabi, Amir, Aharoni, Dorit, Bloch, Olga, Zinger, Heidy, Dayan, Molly, Mozes, Edna
Format: Article
Langue:English
Publié: 2005
Accès à la collection:Clinical immunology (Orlando, Fla.)
Sujets:Journal Article Research Support, Non-U.S. Gov't Autoantibodies Complementarity Determining Regions Peptide Fragments MAP Kinase Kinase 4 EC 2.7.12.2 Proto-Oncogene Proteins p21(ras) EC 3.6.5.2