Fungal metabolite gliotoxin blocks mast cell activation by a calcium- and superoxide-dependent mechanism implications for immunosuppressive activities

Fungal metabolite gliotoxin blocks mast cell activation by a calcium- and superoxide-dependent mechanism : implications for immunosuppressive activities

Fungal secondary metabolites such as gliotoxin, an epipolythiodioxopiperazine toxin produced by pathogenic fungi like Candida and Aspergillus, possess immunosuppressive activities and have been thought to contribute to pathology of fungal infections in animals and humans. Since recent studies show t...

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Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 118(2006), 1 vom: 01. Jan., Seite 108-16
1. Verfasser: Niide, Osamu (VerfasserIn)
Weitere Verfasser: Suzuki, Yoshihiro, Yoshimaru, Tetsuro, Inoue, Toshio, Takayama, Tadatoshi, Ra, Chisei
Format: Aufsatz
Sprache:English
Veröffentlicht: 2006
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Immunosuppressive Agents Interleukin-13 Receptors, IgE Tumor Necrosis Factor-alpha Superoxides 11062-77-4 Leukotriene C4 2CU6TT9V48 mehr... Gliotoxin 67-99-2 Calcium SY7Q814VUP