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01000naa a22002652 4500 |
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NLM15782389X |
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DE-627 |
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20231223080956.0 |
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tu |
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231223s2006 xx ||||| 00| ||eng c |
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2 |
|a pubmed24n0526.xml
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|a (DE-627)NLM15782389X
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|a (NLM)16168712
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Liang, Wei
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a B-cell delivered gene transfer of human S-Ag-Ig fusion protein protects from experimental autoimmune uveitis
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| 264 |
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1 |
|c 2006
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 03.03.2006
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| 500 |
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|a Date Revised 15.11.2012
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| 500 |
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|a published: Print-Electronic
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|a ErratumIn: Clin Immunol. 2006 Sep;120(3):357 Mattapallil, Mary [added]; Caspi, Rachel [added]
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|a Citation Status MEDLINE
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| 520 |
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|a Uveitis is an important autoimmune disease affecting an estimated 2.3 million Americans. This disease is manifested by inflammation of the retina mediated by the infiltration of T lymphocytes that recognize "S-Antigen" (S-Ag). Current therapies involve the life-long use of immunosuppressive drugs, including steroids. The ability to induce specific tolerance to S-Ag would be desirable and allow patients to be weaned off of steroid therapy. In this study, we determined that S-Ag-Ig retroviral vector was capable of preventing EAU (experimental autoimmune uveoretinitis) in Lewis rats induced by immunization with bovine S-Ag (BoS-Ag). Importantly, B-cell delivered gene therapy with S-Ag-Ig can ameliorate ongoing EAU when the treatment was initiated after rats had been immunized. Furthermore, we have successfully induced tolerance in HLA-DR3 transgenic mice with respect to the T-cell proliferative response. These results demonstrate proof of principle for future efforts to develop this approach for clinical application in patients with uveoretinitis
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, N.I.H., Extramural
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| 650 |
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7 |
|a Arrestin
|2 NLM
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| 650 |
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7 |
|a Immunoglobulin G
|2 NLM
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| 650 |
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7 |
|a Recombinant Fusion Proteins
|2 NLM
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| 700 |
1 |
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|a Karabekian, Zaruhi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Mattapallil, Mary
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xu, Qihong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Viley, Angelia M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Caspi, Rachel
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Scott, David W
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 118(2006), 1 vom: 01. Jan., Seite 35-41
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:118
|g year:2006
|g number:1
|g day:01
|g month:01
|g pages:35-41
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
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| 951 |
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|a AR
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|d 118
|j 2006
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|h 35-41
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