Fcgamma-receptor IIA genotype and invasive pneumococcal infection

Streptococcus pneumoniae is a major cause of pneumonia, bacteraemia, meningitis, and acute otitis media, especially in young children, immunocompromised patients, and elderly. Fcgamma-IIA receptor plays a crucial role in the phagocytosis of IgG2-opsonized bacteria since it is the sole receptor able...

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Détails bibliographiques
Publié dans:Clinical immunology (Orlando, Fla.). - 1999. - 118(2006), 1 vom: 01. Jan., Seite 20-3
Auteur principal: Moens, Leen (Auteur)
Autres auteurs: Van Hoeyveld, Erna, Verhaegen, Jan, De Boeck, Kris, Peetermans, Willy E, Bossuyt, Xavier
Format: Article
Langue:English
Publié: 2006
Accès à la collection:Clinical immunology (Orlando, Fla.)
Sujets:Journal Article Antigens, CD Fc gamma receptor IIA Receptors, IgG
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520 |a Streptococcus pneumoniae is a major cause of pneumonia, bacteraemia, meningitis, and acute otitis media, especially in young children, immunocompromised patients, and elderly. Fcgamma-IIA receptor plays a crucial role in the phagocytosis of IgG2-opsonized bacteria since it is the sole receptor able to interact with IgG2 antibodies. Fcgamma-RIIA exhibits allelic polymorphisms with different capacities for binding IgG2 and phagocytosis. In a prospective study, we genotyped Fcgamma-RIIA in 55 Caucasian patients suffering from invasive pneumococcal disease and in 100 Caucasian controls. In contrast to previous reports, we found no association between Fcgamma-RIIA genotype and invasive pneumococcal disease 
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700 1 |a De Boeck, Kris  |e verfasserin  |4 aut 
700 1 |a Peetermans, Willy E  |e verfasserin  |4 aut 
700 1 |a Bossuyt, Xavier  |e verfasserin  |4 aut 
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