Synthetic and natural polycationic polymer nanoparticles interact selectively with fluid-phase domains of DMPC lipid bilayers

Polycationic polymers are known to disrupt lipid bilayers. In this letter, we report the dependence of this disruption on the lipid structural phase. DMPC bilayers are exposed to two polycationic polymeric nanoparticles, PAMAM dendrimers and MSI-78. We find that regions of the bilayer that are in th...

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Veröffentlicht in:Langmuir : the ACS journal of surfaces and colloids. - 1992. - 21(2005), 19 vom: 13. Sept., Seite 8588-90
1. Verfasser: Mecke, Almut (VerfasserIn)
Weitere Verfasser: Lee, Dong-Kuk, Ramamoorthy, Ayyalusamy, Orr, Bradford G, Holl, Mark M Banaszak
Format: Aufsatz
Sprache:English
Veröffentlicht: 2005
Zugriff auf das übergeordnete Werk:Langmuir : the ACS journal of surfaces and colloids
Schlagworte:Journal Article Antimicrobial Cationic Peptides Dendrimers Lipid Bilayers PAMAM Starburst Polyamines Polyelectrolytes Polymers polycations pexiganan mehr... TVF29Q70Q1 Dimyristoylphosphatidylcholine U86ZGC74V5
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245 1 0 |a Synthetic and natural polycationic polymer nanoparticles interact selectively with fluid-phase domains of DMPC lipid bilayers 
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520 |a Polycationic polymers are known to disrupt lipid bilayers. In this letter, we report the dependence of this disruption on the lipid structural phase. DMPC bilayers are exposed to two polycationic polymeric nanoparticles, PAMAM dendrimers and MSI-78. We find that regions of the bilayer that are in the gel phase are unaffected by the presence of polymers, whereas the liquid phase is disrupted 
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700 1 |a Ramamoorthy, Ayyalusamy  |e verfasserin  |4 aut 
700 1 |a Orr, Bradford G  |e verfasserin  |4 aut 
700 1 |a Holl, Mark M Banaszak  |e verfasserin  |4 aut 
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