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01000naa a22002652 4500 |
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NLM157151662 |
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DE-627 |
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20231223075609.0 |
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tu |
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231223s2005 xx ||||| 00| ||eng c |
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2 |
|a pubmed24n0524.xml
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|a (DE-627)NLM157151662
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|a (NLM)16095971
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Deshmukh, Umesh S
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Epitope spreading within lupus-associated ribonucleoprotein antigens
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| 264 |
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1 |
|c 2005
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 08.11.2006
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| 500 |
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|a Date Revised 14.11.2007
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| 500 |
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|a published: Print-Electronic
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| 500 |
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|a Citation Status MEDLINE
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| 520 |
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|a Autoantibodies reactive with several cellular antigens are present in the sera of patients with systemic lupus erythematosus. Polypeptides within the Ro-RNP complex and the snRNP complex are often targeted by these autoantibodies. One of the mechanisms responsible for their evolution is that of epitope spreading. Experimental animal model systems provide evidence for this. This review discusses the animal model systems of epitope spreading within these ribonucleoprotein antigens, the mechanisms of epitope spreading, and its relevance for disease pathogenesis
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, N.I.H., Extramural
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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4 |
|a Research Support, U.S. Gov't, P.H.S.
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| 650 |
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4 |
|a Review
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| 650 |
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7 |
|a Autoantigens
|2 NLM
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| 650 |
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7 |
|a Epitopes
|2 NLM
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| 650 |
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7 |
|a Ribonucleoproteins
|2 NLM
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| 700 |
1 |
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|a Bagavant, Harini
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lewis, Janet
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gaskin, Felicia
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Fu, Shu Man
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 117(2005), 2 vom: 01. Nov., Seite 112-20
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:117
|g year:2005
|g number:2
|g day:01
|g month:11
|g pages:112-20
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 117
|j 2005
|e 2
|b 01
|c 11
|h 112-20
|