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DE-627 |
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20231223075348.0 |
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231223s2005 xx ||||| 00| ||chi c |
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|a pubmed24n0524.xml
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|a (DE-627)NLM157034070
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|a (NLM)16083553
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a chi
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| 100 |
1 |
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|a Xi, Wei-ping
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Association of vitamin D receptor gene Apa I polymorphism with vitamin D deficiency rickets
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| 264 |
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1 |
|c 2005
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 20.07.2010
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| 500 |
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|a Date Revised 07.06.2016
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|a published: Print
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|a Citation Status MEDLINE
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| 520 |
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|a OBJECTIVE: To study the association between vitamin D receptor (VDR) gene Apa I polymorphism and vitamin D deficiency rickets in children of Shanxi Han ethnic group, and to explore the significance of individual hereditary factors in the development of rickets
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|a METHODS: This was a case control study. The grouping criteria were serum 25(OH)D(3) level, blood bone alkaline phosphatase and clinical symptom, respectively. The laboratory test methods were enzyme linked immunoassay and radioimmunoassay. PCR-RFLP technology was applied to examine VDR gene Apa I site polymorphism and Hardy-Weinberg hereditary balance test was used to examine the coincidence of gene distribution
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| 520 |
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|a RESULTS: Frequencies of AA, Aa and aa genotypes were 5.0%, 52.5% and 42.5% in the rickets group and 4.4%, 55.9% and 39.7% in the control group, respectively. Frequencies of A and a genotypes were 31.3% and 68.7% in the rickets group and 32.3% and 67.7% in the control group, respectively. There was not significant difference in the frequency distribution of VDR genotype and allelic genes between two groups (chi(2) = 0.089, P > 0.05; chi(2) = 0.028, P > 0.05). There was significant difference in the serum 25(OH)D(3) between two groups (t = -8.919, P < 0.01)
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| 520 |
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|a CONCLUSION: The distribution of VDR gene Apa I polymorphism in children of Han ethnic group is balanced relatively. The Frequency of a allelic genes is 67.7% which is therefore the superior gene. VDR gene polymorphism might not be important in an individual's susceptibility to development of vitamin D deficiency
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| 650 |
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|a English Abstract
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4 |
|a Journal Article
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| 650 |
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|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a Receptors, Calcitriol
|2 NLM
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| 650 |
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7 |
|a Calcitriol
|2 NLM
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| 650 |
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|2 NLM
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| 650 |
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7 |
|a P6YZ13C99Q
|2 NLM
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| 700 |
1 |
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|a Yang, Jian-ping
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Lian-qing
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhu, Qing-yi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhou, Xiang-hong
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Zhonghua er ke za zhi = Chinese journal of pediatrics
|d 1960
|g 43(2005), 7 vom: 08. Juli, Seite 514-6
|w (DE-627)NLM136249191
|x 0578-1310
|7 nnns
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| 773 |
1 |
8 |
|g volume:43
|g year:2005
|g number:7
|g day:08
|g month:07
|g pages:514-6
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|d 43
|j 2005
|e 7
|b 08
|c 07
|h 514-6
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