Potential use of a Yersinia ruckeri O1 auxotrophic aroA mutant as a live attenuated vaccine

Potential use of a Yersinia ruckeri O1 auxotrophic aroA mutant as a live attenuated vaccine

The aroA gene of Yersinia ruckeri, which encodes 5-enolpyruvylshikimate 3-phosphate synthase, was insertionally inactivated with a DNA fragment containing a kanamycin resistance determinant and reintroduced by allelic exchange into the chromosome of Y. ruckeri 21102 O1 by means of the suicide vector...

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Détails bibliographiques
Publié dans:Journal of fish diseases. - 1998. - 28(2005), 7 vom: 15. Juli, Seite 419-27
Auteur principal: Temprano, A (Auteur)
Autres auteurs: Riaño, J, Yugueros, J, González, P, de Castro, L, Villena, A, Luengo, J M, Naharro, G
Format: Article
Langue:English
Publié: 2005
Accès à la collection:Journal of fish diseases
Sujets:Comparative Study Journal Article Research Support, Non-U.S. Gov't Bacterial Vaccines