Anti-TWEAK monoclonal antibodies reduce immune cell infiltration in the central nervous system and severity of experimental autoimmune encephalomyelitis

Anti-TWEAK monoclonal antibodies reduce immune cell infiltration in the central nervous system and severity of experimental autoimmune encephalomyelitis

TWEAK is a member of the TNF family, constitutively expressed in the central nervous system (CNS), with pro-inflammatory, proliferative or apoptotic effects depending upon cell types. Its receptor, Fn14, is expressed in CNS by endothelial cells, reactive astrocytes and neurons. We showed that TWEAK...

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Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 117(2005), 1 vom: 01. Okt., Seite 15-23
1. Verfasser: Desplat-Jégo, Sophie (VerfasserIn)
Weitere Verfasser: Creidy, Rita, Varriale, Simone, Allaire, Normand, Luo, Yi, Bernard, Dominique, Hahm, Kyungmin, Burkly, Linda, Boucraut, José
Format: Aufsatz
Sprache:English
Veröffentlicht: 2005
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Antibodies, Monoclonal Apoptosis Regulatory Proteins Carrier Proteins Cytokine TWEAK Tnfsf12 protein, mouse Tumor Necrosis Factors