Blocking of interleukin-10 receptor--a novel approach to stimulate T-helper cell type 1 responses to hepatitis C virus

Blocking of interleukin-10 receptor--a novel approach to stimulate T-helper cell type 1 responses to hepatitis C virus

Chronic hepatitis C virus (HCV) infection is associated with weak CD4+ T-helper type 1 reactivity and enhanced interleukin-10 production to HCV antigens. Here we demonstrate in vitro that monoclonal antibody-induced blockade of IL-10 receptor (IL-10R) generates a favorable balance of CD4+ T-cell res...

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Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 117(2005), 1 vom: 05. Okt., Seite 57-64
1. Verfasser: Rigopoulou, Eirini I (VerfasserIn)
Weitere Verfasser: Abbott, William G H, Haigh, Philip, Naoumov, Nikolai V
Format: Aufsatz
Sprache:English
Veröffentlicht: 2005
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Comparative Study Journal Article Research Support, Non-U.S. Gov't Antibodies, Monoclonal Receptors, Interleukin Receptors, Interleukin-10 Interleukin-10 130068-27-8 Interferon-gamma 82115-62-6