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231223s2005 xx ||||| 00| ||chi c |
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|a pubmed25n0522.xml
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|a (DE-627)NLM156423405
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|a (NLM)16004775
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|a DE-627
|b ger
|c DE-627
|e rakwb
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041 |
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|a chi
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100 |
1 |
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|a Yan, Guang-tao
|e verfasserin
|4 aut
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245 |
1 |
0 |
|a Changes of serum leptin level in pulmonary infection-induced multiple organ dysfunction syndrome
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|c 2005
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336 |
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|a Text
|b txt
|2 rdacontent
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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338 |
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|a Band
|b nc
|2 rdacarrier
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500 |
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|a Date Completed 05.01.2010
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500 |
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|a Date Revised 11.07.2005
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|a published: Print
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|a Citation Status MEDLINE
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|a OBJECTIVE: To determine serum levels of leptin and some related cytokines in severely ill patients, including severe pulmonary infection-induced multiple organ dysfunction syndrome (MODS), acute myocardial infarction (AMI) and arrhythmia (AR), and to explore the possible role of leptin in the pathogenesis and diagnosis of MODS
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|a METHODS: Radioimmunoassay was used to determine leptin, fatty acid binding protein (FABP), transferrin (Ferr) and interleukin-1beta (IL-1beta), and enzyme-linked immuno adsorbent assay (ELISA) was used to assess C reactive protein (CRP)
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|a RESULTS: Compared with normal individuals, leptin levels in MODS, AMI and AR patients increased significantly (all P<0.01). CRP and IL-1beta levels also increased significantly in MODS, AMI and AR patients, but the changes were more marked (all P<0.05) in MODS patients than in the patients of other two diseases (both P<0.05). Though FABP and Ferr levels of patients in all the three groups of patients showed a trend toward increase, especially in MODS patients, there was no significant difference between them and normal individuals
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|a CONCLUSION: Serum leptin level increases significantly in pulmonary infection-induced MODS patients with a simultaneous increase of CRP and IL-1beta levels, and the result suggests that leptin plays a possible role in the pathogenesis and prognosis of MODS
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650 |
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|a English Abstract
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650 |
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4 |
|a Journal Article
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4 |
|a Research Support, Non-U.S. Gov't
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650 |
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7 |
|a Fatty Acid-Binding Proteins
|2 NLM
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650 |
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7 |
|a Interleukin-1beta
|2 NLM
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650 |
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7 |
|a Leptin
|2 NLM
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650 |
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7 |
|a C-Reactive Protein
|2 NLM
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650 |
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7 |
|a 9007-41-4
|2 NLM
|
700 |
1 |
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|a Xue, Hui
|e verfasserin
|4 aut
|
700 |
1 |
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|a Lin, Ji
|e verfasserin
|4 aut
|
700 |
1 |
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|a Hao, Xiu-hua
|e verfasserin
|4 aut
|
700 |
1 |
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|a Zhang, Kai
|e verfasserin
|4 aut
|
700 |
1 |
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|a Wang, Lu-huan
|e verfasserin
|4 aut
|
773 |
0 |
8 |
|i Enthalten in
|t Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
|d 1998
|g 17(2005), 7 vom: 11. Juli, Seite 399-402
|w (DE-627)NLM098227793
|x 1003-0603
|7 nnns
|
773 |
1 |
8 |
|g volume:17
|g year:2005
|g number:7
|g day:11
|g month:07
|g pages:399-402
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912 |
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|a GBV_ILN_350
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951 |
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|a AR
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952 |
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|d 17
|j 2005
|e 7
|b 11
|c 07
|h 399-402
|