Activated cytotoxic T cells and NK cells in severe sepsis and septic shock and their role in multiple organ dysfunction

To evaluate the role of activated cytotoxic cells in patients with severe sepsis (n = 32) or septic shock (n = 8), direct (granzymes A and B) as well as indirect markers (cytokines) for cytotoxic cell activation were measured. Elevated IL-12p40 levels had been detected in 58% of the sepsis patients,...

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Veröffentlicht in:	Clinical immunology (Orlando, Fla.). - 1999. - 116(2005), 2 vom: 01. Aug., Seite 158-65
1. Verfasser:	Zeerleder, Sacha (VerfasserIn)
Weitere Verfasser:	Hack, C Erik, Caliezi, Christoph, van Mierlo, Gerard, Eerenberg-Belmer, Anke, Wolbink, Angela, Wuillenmin, Walter A
Format:	Aufsatz
Sprache:	English
Veröffentlicht:	2005
Zugriff auf das übergeordnete Werk:	Clinical immunology (Orlando, Fla.)
Schlagworte:	Journal Article Research Support, Non-U.S. Gov't Cytokines Interleukin-12 Subunit p40 Interleukin-6 Nucleosomes Plasminogen Activator Inhibitor 1 Protein Subunits alpha-2-Antiplasmin antithrombin III-protease complex mehr... fas Receptor plasmin-plasmin inhibitor complex Interleukin-12 187348-17-0 Antithrombin III 9000-94-6 Peptide Hydrolases EC 3.4.- GZMB protein, human EC 3.4.21.- Granzymes Serine Endopeptidases Fibrinolysin EC 3.4.21.7 GZMA protein, human EC 3.4.21.78

Beschreibung
Zusammenfassung:	To evaluate the role of activated cytotoxic cells in patients with severe sepsis (n = 32) or septic shock (n = 8), direct (granzymes A and B) as well as indirect markers (cytokines) for cytotoxic cell activation were measured. Elevated IL-12p40 levels had been detected in 58% of the sepsis patients, whereas only a few had detectable TNF-alpha, IFN-gamma, or IL-12p70 levels. Granzymes A and B levels were elevated in 42.5% and 22.5%, respectively. IL-12p40 inversely correlated with disease severity. Inflammatory parameters (IL-6) and coagulation markers were significantly lower and higher, respectively, in patients with elevated IL-12p40 and granzyme B levels, as compared to those with normal levels. Elevation of granzyme A directly correlated with the increase of apoptotic markers. Activated cytotoxic cells reflected by elevated granzymes A and/or B were found in 50% of our sepsis patients. This group showed a higher mortality and a worse organ function
Beschreibung:	Date Completed 12.09.2005 Date Revised 16.11.2017 published: Print Citation Status MEDLINE
ISSN:	1521-7035