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NLM156096218 |
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DE-627 |
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20250206115858.0 |
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231223s2005 xx ||||| 00| ||chi c |
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|a pubmed25n0520.xml
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|a (DE-627)NLM156096218
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|a (NLM)15970107
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a chi
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| 100 |
1 |
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|a Zhang, Qiu-jin
|e verfasserin
|4 aut
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1 |
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|a Effects of combined naloxone and methylprednisolone on nuclear factor-kappaB expression in the lung in acute lung injury in rats
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|c 2005
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|a Text
|b txt
|2 rdacontent
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 15.12.2009
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|a Date Revised 21.11.2013
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|a published: Print
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|a Citation Status MEDLINE
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|a OBJECTIVE: To investigate the effects of a combination of naloxone and methylprednisolone on nuclear factor-kappaB (NF-kappaB) p65 expression in the lung tissue in lipopolysaccharide (LPS)-induced acute lung injury (ALI) in rats
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|a METHODS: ALI models were reproduced by intratracheal instillation of LPS (3 mg/kg). Four hours after LPS instillation, rats were randomly divided into five groups: normal saline group, LPS group, methylprednisolone group, naloxone group (LPS+naloxone) and combined drug group (LPS+naloxone+methylprednisolone). The level of interleukin-8 (IL-8) in serum was measured by immunoassay. Meanwhile, the expression of NF-kappaB p65 in the lung tissue was determined with immunohistochemical staining
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|a RESULTS: Naloxone and methylprednisolone significantly reduced the LPS-induced increase in IL-8 concentrations in serum in vivo, and suppressed the activation of NF-kappaB p65 in the lung tissue
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|a CONCLUSION: NF-kappaB activation is involved in the LPS-induced ALI in rats. Combination of naloxone and methylprednisolone could suppress the increase of IL-8 content and NF-kappaB activation in the lung tissue of rat in vivo in our experiment
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|a English Abstract
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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| 650 |
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|a Interleukin-8
|2 NLM
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| 650 |
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|a Lipopolysaccharides
|2 NLM
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| 650 |
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|a NF-kappa B
|2 NLM
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| 650 |
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|a Naloxone
|2 NLM
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| 650 |
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7 |
|a 36B82AMQ7N
|2 NLM
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| 650 |
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7 |
|a Methylprednisolone
|2 NLM
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| 650 |
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7 |
|a X4W7ZR7023
|2 NLM
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| 700 |
1 |
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|a Shen, Hong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Wei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Yin-ping
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Tan-shi
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
|d 1998
|g 17(2005), 6 vom: 16. Juni, Seite 370-2
|w (DE-627)NLM098227793
|x 1003-0603
|7 nnns
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| 773 |
1 |
8 |
|g volume:17
|g year:2005
|g number:6
|g day:16
|g month:06
|g pages:370-2
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|a GBV_USEFLAG_A
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|a SYSFLAG_A
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|a GBV_NLM
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 17
|j 2005
|e 6
|b 16
|c 06
|h 370-2
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