Electrochemically induced and controlled one-step covalent coupling reaction on self-assembled monolayers
We report on a novel covalent coupling method using electrochemical activation of hydroquinone monoester self-assembled monolayers. The reaction generates benzoquinone as a good leaving group, followed by nucleophilic acyl substitution with a primary amine to form an amide in high yield. The method...
| Veröffentlicht in: | Langmuir : the ACS journal of surfaces and colloids. - 1992. - 20(2004), 10 vom: 11. Mai, Seite 3821-3 |
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| 1. Verfasser: | |
| Weitere Verfasser: | , , , , |
| Format: | Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
2004
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| Zugriff auf das übergeordnete Werk: | Langmuir : the ACS journal of surfaces and colloids |
| Schlagworte: | Letter |
| Zusammenfassung: | We report on a novel covalent coupling method using electrochemical activation of hydroquinone monoester self-assembled monolayers. The reaction generates benzoquinone as a good leaving group, followed by nucleophilic acyl substitution with a primary amine to form an amide in high yield. The method allows the site-selective and the reaction-controlled positioning of biotin on the individually addressable microelectrode array and, subsequently, density-differentiated patterning of streptavidin on the biotin surfaces. Because the electrochemical coupling method provides a very rapid, mild, and quantitatively controllable reaction pathway for covalent bond formation on organic surfaces, it will be used as a versatile molecular anchoring tool in fields such as molecular electronics and biochip technology |
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| Beschreibung: | Date Completed 31.01.2006 Date Revised 26.10.2019 published: Print Citation Status PubMed-not-MEDLINE |
| ISSN: | 1520-5827 |