Simvastatin induces interleukin-18 production in human peripheral blood mononuclear cells

Simvastatin induces interleukin-18 production in human peripheral blood mononuclear cells

The effects of statins on immune response depend on the inhibition of 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductase and leukocyte function-associated antigen (LFA)-1, which is a ligand of intercellular adhesion molecule (ICAM)-1. Simvastatin, an HMG-CoA reductase inhibitor with mild inhi...

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Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 116(2005), 3 vom: 15. Sept., Seite 211-6
1. Verfasser: Takahashi, Hideo Kohka (VerfasserIn)
Weitere Verfasser: Mori, Shuji, Iwagaki, Hiromi, Yoshino, Tadashi, Tanaka, Noriaki, Nishibori, Masahiro
Format: Aufsatz
Sprache:English
Veröffentlicht: 2005
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Antibodies, Monoclonal Antigens, CD B7-1 Antigen B7-2 Antigen CD40 Antigens CD86 protein, human Hydroxymethylglutaryl-CoA Reductase Inhibitors Interleukin-18 mehr... Lymphocyte Function-Associated Antigen-1 Membrane Glycoproteins Tumor Necrosis Factor-alpha tyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone Intercellular Adhesion Molecule-1 126547-89-5 Interleukin-10 130068-27-8 CD40 Ligand 147205-72-9 Interleukin-12 187348-17-0 Tosylphenylalanyl Chloromethyl Ketone 402-71-1 Interferon-gamma 82115-62-6 Simvastatin AGG2FN16EV Mevalonic Acid S5UOB36OCZ