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231223s2005 xx ||||| 00| ||eng c |
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|a (NLM)15925829
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Kuss, Iris
|e verfasserin
|4 aut
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| 245 |
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|a Recent thymic emigrants and subsets of naive and memory T cells in the circulation of patients with head and neck cancer
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|c 2005
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|a Text
|b txt
|2 rdacontent
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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|b nc
|2 rdacarrier
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|a Date Completed 09.08.2005
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|a Date Revised 14.11.2007
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|a published: Print
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|a Citation Status MEDLINE
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|a Apoptosis of circulating CD8+ T lymphocytes is a frequent finding in patients with cancer. T-cell output by the thymus or antigen-driven expansion of circulating T cells could compensate for apoptosis and thus normalize their homeostasis. We studied the frequency of recent thymic emigrants (RTE) identified by T-cell receptor excision circles (TREC) and of naive and memory T-cell subsets in peripheral blood samples obtained from 39 patients with head and neck cancer (HNC) and 33 age-matched controls (NC). TREC numbers were determined by real-time quantitative PCR, and CD8+CD45RO-CD27+ or CD4+CD45RO-CD27+ T-cell subsets were quantified by flow cytometry. Age-associated decreases in TREC numbers and proportions of naive CD8+ and CD4+ T-cell subsets were significantly greater in cancer patients than NC. In contrast, the memory compartment was expanded, with increased proportions of CD4+CD45RO+ but not CD8+CD45RO+ T cells, in cancer patients vs. NC. These alterations did not normalize in patients who were NED. The data suggest that lower thymic output combined with rapid turnover of naive CD8+ T cells account for altered lymphocyte homeostasis in HNC patients. The defect persists long after curative treatments and may contribute to immune cell dysregulation in patients with cancer
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|a Journal Article
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| 650 |
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|a Research Support, N.I.H., Extramural
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| 650 |
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|a Research Support, Non-U.S. Gov't
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| 650 |
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|a Research Support, U.S. Gov't, P.H.S.
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| 650 |
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|a Receptors, Antigen, T-Cell
|2 NLM
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| 700 |
1 |
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|a Schaefer, Carsten
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Godfrey, Tony E
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ferris, Robert L
|e verfasserin
|4 aut
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| 700 |
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|a Harris, Jeffrey M
|e verfasserin
|4 aut
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| 700 |
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|a Gooding, William
|e verfasserin
|4 aut
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| 700 |
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|a Whiteside, Theresa L
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 116(2005), 1 vom: 30. Juli, Seite 27-36
|w (DE-627)NLM098196855
|x 1521-6616
|7 nnns
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| 773 |
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|g volume:116
|g year:2005
|g number:1
|g day:30
|g month:07
|g pages:27-36
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