Serum neopterin for early assessment of severity of severe acute respiratory syndrome

Neopterin and C-reactive protein (CRP) concentrations were determined in serum samples from 129 severe acute respiratory syndrome (SARS) patients and 156 healthy blood donors. In the patients with confirmed SARS, an early neopterin elevation was detected already at the day of onset of symptoms and r...

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Veröffentlicht in:	Clinical immunology (Orlando, Fla.). - 1999. - 116(2005), 1 vom: 30. Juli, Seite 18-26
1. Verfasser:	Zheng, Bojian (VerfasserIn)
Weitere Verfasser:	Cao, Kai-Yuan, Chan, Cangel P Y, Choi, Junet W Y, Leung, Wingman, Leung, Manfai, Duan, Zhao-Hui, Gao, Yang, Wang, Ming, Di, Biao, Hollidt, Jörg M, Bergmann, Andreas, Lehmann, Matthias, Renneberg, Ilka, Tam, John S L, Chan, Paul K S, Cautherley, George W H, Fuchs, Dietmar, Renneberg, Reinhard
Format:	Aufsatz
Sprache:	English
Veröffentlicht:	2005
Zugriff auf das übergeordnete Werk:	Clinical immunology (Orlando, Fla.)
Schlagworte:	Journal Article Research Support, Non-U.S. Gov't Adrenal Cortex Hormones Antibodies Biomarkers Neopterin 670-65-5

Beschreibung
Zusammenfassung:	Neopterin and C-reactive protein (CRP) concentrations were determined in serum samples from 129 severe acute respiratory syndrome (SARS) patients and 156 healthy blood donors. In the patients with confirmed SARS, an early neopterin elevation was detected already at the day of onset of symptoms and rose to a maximum level of 45.0 nmol/L 3 days after the onset. All SARS patients had elevated neopterin concentrations (>10 nmol/L) within 9 days after the onset. The mean neopterin concentrations were 34.2 nmol/L in acute sera of SARS patients, 5.1 nmol/L in convalescent sera, and 6.7 nmol/L in healthy controls. In contrast, the mean CRP concentrations in both acute and convalescent sera of SARS patients were in the normal range (<10 mg/L). Serum neopterin level in SARS patients was associated with fever period and thus the clinical progression of the disease, while there was no significant correlation between the CRP level and the fever period. Serum neopterin may allow early assessment of the severity of SARS. The decrease of neopterin level was found after steroid treatment, which indicates that blood samples should be collected before steroid treatment for the neopterin measurement
Beschreibung:	Date Completed 09.08.2005 Date Revised 02.04.2020 published: Print Citation Status MEDLINE
ISSN:	1521-7035