IgA : an immune glycoprotein
IgA is a glycoprotein containing multiple N-linked carbohydrates as well as O-linked glycans in the case of IgA1. Because of the critical role it plays in providing protection at mucosal surfaces, IgA is an ideal candidate for use as a therapeutic or prophylactic agent. The presence or absence of ca...
| Veröffentlicht in: | Clinical immunology (Orlando, Fla.). - 1999. - 116(2005), 1 vom: 30. Juli, Seite 3-10 |
|---|---|
| 1. Verfasser: | |
| Weitere Verfasser: | |
| Format: | Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
2005
|
| Zugriff auf das übergeordnete Werk: | Clinical immunology (Orlando, Fla.) |
| Schlagworte: | Journal Article Review Glycoproteins IgA receptor Immunoglobulin A Receptors, Fc Peptide Hydrolases EC 3.4.- |
| Zusammenfassung: | IgA is a glycoprotein containing multiple N-linked carbohydrates as well as O-linked glycans in the case of IgA1. Because of the critical role it plays in providing protection at mucosal surfaces, IgA is an ideal candidate for use as a therapeutic or prophylactic agent. The presence or absence of carbohydrates, as well as their structure, has been found to influence effector functions and binding to specific IgA receptors. In addition, changes in IgA glycosylation are associated with immune pathology. A thorough understanding of the contributions of the glycans to IgA immune protection will aid in the design of clinically suitable antibodies |
|---|---|
| Beschreibung: | Date Completed 09.08.2005 Date Revised 16.11.2005 published: Print Citation Status MEDLINE |
| ISSN: | 1521-7035 |