Comprehensive examination of mesophases formed by DMPC and DHPC mixtures

Mixtures of long- and short-chain phospholipids, specifically 14:0 and 6:0 phosphatidylcholines (DMPC and DHPC), have been used successfully in NMR studies as magnetically alignable substrates for membrane-associated proteins. However, recent publications have shown that the phase behavior of these...

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Veröffentlicht in:Langmuir : the ACS journal of surfaces and colloids. - 1992. - 21(2005), 12 vom: 07. Juni, Seite 5356-61
1. Verfasser: Harroun, Thad A (VerfasserIn)
Weitere Verfasser: Koslowsky, Martin, Nieh, Mu-Ping, de Lannoy, Charles-François, Raghunathan, V A, Katsaras, John
Format: Aufsatz
Sprache:English
Veröffentlicht: 2005
Zugriff auf das übergeordnete Werk:Langmuir : the ACS journal of surfaces and colloids
Schlagworte:Journal Article
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245 1 0 |a Comprehensive examination of mesophases formed by DMPC and DHPC mixtures 
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520 |a Mixtures of long- and short-chain phospholipids, specifically 14:0 and 6:0 phosphatidylcholines (DMPC and DHPC), have been used successfully in NMR studies as magnetically alignable substrates for membrane-associated proteins. However, recent publications have shown that the phase behavior of these mixtures is much more complex than originally thought. Using polarized light microscopy and small-angle neutron scattering, phase diagrams of DMPC/DHPC mixtures at molar ratios of 2, 3.2, and 5 have been determined. Generally, at temperatures below the main-chain melting transition of DMPC (T(M) = 23 degrees C), an isotropic phase of disk-like micelles is found. At high temperatures (T > 50 degrees C), a lamellar phase consisting of either multilamellar vesicles (MLV) or extended lamellae is formed, which at low lipid concentrations (e.g., MLV) coexists with an excess of water. At intermediate temperatures and lipid concentrations, a chiral nematic phase made up of worm-like micelles was observed 
650 4 |a Journal Article 
700 1 |a Koslowsky, Martin  |e verfasserin  |4 aut 
700 1 |a Nieh, Mu-Ping  |e verfasserin  |4 aut 
700 1 |a de Lannoy, Charles-François  |e verfasserin  |4 aut 
700 1 |a Raghunathan, V A  |e verfasserin  |4 aut 
700 1 |a Katsaras, John  |e verfasserin  |4 aut 
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