Block copolymers of ethylene oxide and phenyl glycidyl ether : micellization, gelation, and drug solubilization

Three triblock copolymers of ethylene oxide and phenyl glycidyl ether, type E(m)G(n)E(m), where G = OCH2CH(CH2OC6H5) and E = OCH2CH2, were synthesized and characterized by gel-permeation chromatography, matrix-assisted laser desorption ionization time-of-flight mass spectrometry, and NMR spectroscop...

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Bibliographische Detailangaben
Veröffentlicht in:	Langmuir : the ACS journal of surfaces and colloids. - 1992. - 21(2005), 12 vom: 07. Juni, Seite 5263-71
1. Verfasser:	Taboada, Pablo (VerfasserIn)
Weitere Verfasser:	Velasquez, Gemma, Barbosa, Silvia, Castelletto, Valeria, Nixon, S Keith, Yang, Zhuo, Heatley, Frank, Hamley, Ian W, Ashford, Marianne, Mosquera, Victor, Attwood, David, Booth, Colin
Format:	Aufsatz
Sprache:	English
Veröffentlicht:	2005
Zugriff auf das übergeordnete Werk:	Langmuir : the ACS journal of surfaces and colloids
Schlagworte:	Journal Article Research Support, Non-U.S. Gov't Antifungal Agents Ethylene Glycols Gels Micelles Phenyl Ethers Polymers styrene glycol 2ZAC511UK8 mehr... Griseofulvin 32HRV3E3D5 Ethylene Oxide JJH7GNN18P

Beschreibung
Zusammenfassung:	Three triblock copolymers of ethylene oxide and phenyl glycidyl ether, type E(m)G(n)E(m), where G = OCH2CH(CH2OC6H5) and E = OCH2CH2, were synthesized and characterized by gel-permeation chromatography, matrix-assisted laser desorption ionization time-of-flight mass spectrometry, and NMR spectroscopy. Their association properties in aqueous solution were investigated by surface tensiometry and light scattering, yielding values of the critical micelle concentration (cmc), the hydrodynamic radius, and the association number. Gel boundaries in concentrated micellar solution were investigated by tube inversion, and for one copolymer, the temperature and frequency dependence of the dynamic moduli served to confirm and extend the phase diagram and to highlight gel properties. Small-angle X-ray scattering was used to investigate gel structure. The overall aim of the work was to define a block copolymer micellar system with better solubilization capacity for poorly soluble aromatic drugs than had been achieved so far by use of block copoly(oxyalkylene)s. Judged by the solubilization of griseofulvin in aqueous solutions of the E(m)G(n)E(m) copolymers, this aim was achieved
Beschreibung:	Date Completed 28.07.2006 Date Revised 24.11.2016 published: Print Citation Status MEDLINE
ISSN:	1520-5827