Regulation of p38 MAP kinase in CD4+ lymphocytes by infliximab therapy in patients with rheumatoid arthritis

Regulation of p38 MAP kinase in CD4+ lymphocytes by infliximab therapy in patients with rheumatoid arthritis

Tumor necrosis factor alpha (TNFalpha) plays a key role in the pathogenesis of rheumatoid arthritis (RA) and most patients treated with anti-TNFalpha agents show significant improvement in both signs and symptoms. While TNFalpha inhibitors rapidly reduce joint inflammation, the mechanisms by which t...

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Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 116(2005), 2 vom: 01. Aug., Seite 101-7
1. Verfasser: Garfield, Bruce E (VerfasserIn)
Weitere Verfasser: Krahl, Troy, Appel, Stacia, Cooper, Sheldon M, Rincón, Mercedes
Format: Aufsatz
Sprache:English
Veröffentlicht: 2005
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Clinical Trial Journal Article Research Support, Non-U.S. Gov't Antibodies, Monoclonal Antirheumatic Agents Interleukin-6 Lipopolysaccharide Receptors Tumor Necrosis Factor-alpha Interferon-gamma 82115-62-6 mehr... Infliximab B72HH48FLU p38 Mitogen-Activated Protein Kinases EC 2.7.11.24