Increased prevalence of transfusion-transmitted virus and cross-reactivity with immunodominant epitopes of the HRES-1/p28 endogenous retroviral autoantigen in patients with systemic lupus erythematosus

Increased prevalence of transfusion-transmitted virus and cross-reactivity with immunodominant epitopes of the HRES-1/p28 endogenous retroviral autoantigen in patients with systemic lupus erythematosus

OBJECTIVE: Systemic lupus erythematosus (SLE) patients produce autoantibodies to HRES-1/p28, a human endogenous retrovirus-encoded nuclear protein. To identify cross-reactive viral antigens capable of triggering autoreactivity, HRES-1/p28 epitopes were mapped by SLE antibodies

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 116(2005), 2 vom: 15. Aug., Seite 124-34
1. Verfasser: Gergely, Peter Jr (VerfasserIn)
Weitere Verfasser: Pullmann, Rudolf, Stancato, Christina, Otvos, Laszlo Jr, Koncz, Agnes, Blazsek, Antal, Poor, Gyula, Brown, Kevin E, Phillips, Paul E, Perl, Andras
Format: Aufsatz
Sprache:English
Veröffentlicht: 2005
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Comparative Study Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Antibodies Antigens, Nuclear Autoantigens Epitopes, B-Lymphocyte HRES-1 p28 protein, human retroviral element mehr... Immunodominant Epitopes Peptide Fragments Retroviridae Proteins Viral Proteins